The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TGF-β Regulates Production of Growth Factors and TGF-β by Human Peripheral Blood Monocytes
Abstract
Transforming growth factor beta 1 (TGF-beta 1) and its closely related homologue, TGF-beta 2, rapidly induce growth factor gene expression by freshly isolated human peripheral blood monocytes. Within 3 h of exposure to TGF-beta, mRNA species specific for interleukin-1 (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF) were observed. By 14-18 h, cytokine bioactivity and protein were detected in the culture supernatants. Furthermore, not only TGF-beta 1, but also TGF-beta 2 mRNA are expressed constitutively in unstimulated monocytes. However, in response to exogenous TGF-beta (beta 1 or beta 2), only TGF-beta 1 gene expression is upregulated, and the expression of TGF-beta 2 mRNA is unchanged. This selective autoinduction of TGF-beta 1 appears to be controlled at both transcriptional and post-transcriptional levels. These paracrine and autocrine activities of TGF-beta suggest potential mechanisms through which an inflammatory response can be initiated and amplified. In addition, the TGF-beta enhancement of growth factor generation may promote fibrosis and angiogenesis relevant to physiological tissue repair as well as pathological fibrotic sequelae.
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Cites
Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.
Postlethwaite, A. E., Keski-Oja, J., Moses, H. L., & Kang, A. H. (1987) · The Journal of experimental medicine · doi:10.1084/jem.165.1.251 · Cited by 777
Cited by
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205
Cellular and Molecular Dynamics in the Foreign Body Reaction
Luttikhuizen, D. T., Harmsen, M. C., & Luyn, M. J. A. V. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.1955 · Cited by 396
Metadata
- Authors
- McCartney-Francis, N., Mizel, D., Wong, H., Wahl, L., & Wahl, S.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 1990-01
- Volume
- 4
- Issue
- 1
- Pages
- 27-35
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W2107658520
- Cited by
- 173
- References
- 1
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- McCartney-Francis, N., Mizel, D., Wong, H., Wahl, L., & Wahl, S. (1990). TGF-β Regulates Production of Growth Factors and TGF-β by Human Peripheral Blood Monocytes. Growth Factors. https://doi.org/10.3109/08977199009011007
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