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Platelet-Derived Growth Factor is Angiogenic In Vivo
Abstract
PDGF receptors have recently been found to be expressed in microvascular endothelium in vivo under circumstances of endothelial cell activation and angiogenesis suggesting that PDGF may have a direct effect on endothelial cells. We have tested the angiogenic activity of PDGF-AA and -BB homodimers in the chick chorioallantoic membrane in vivo. PDGF-BB was found to consistently induce an angiogenic response whereas PDGF-AA was less active. Morphological analyses revealed that there was little inflammation associated with this response but an increase in vessel density suggested a direct effect of PDGF on embryonic chorioallantoic endothelial cells. In vitro, PDGF-BB was found to be more potent than PDGF-AA in stimulating the chemotaxis of rat brain capillary endothelial cells. This is consistent with a direct effect of PDGF on endothelial cells. Thus, this novel angiogenic activity of PDGF has implications for several developmental and pathological events in which PDGF, particularly the B-chain, is expressed.
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Cited by
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Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.
Frank, S., Hübner, G., Breier, G., Longaker, M. T., Greenhalgh, D. G., & Werner, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12607 · Cited by 764
Carano, R. A. D., & Filvaroff, E. H. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02866-6 · Cited by 746
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Bonnet, C. S. (2005) · Rheumatology · doi:10.1093/rheumatology/keh344 · Cited by 709
Pertovaara, L., Kaipainen, A., Mustonen, T., Orpana, A., Ferrara, N., Saksela, O., & Alitalo, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37365-9 · Cited by 694
Metadata
- Authors
- Risau, W., Drexler, H., Mironov, V., Smits, A., Siegbahn, A., Funa, K., & Heldin, C.-H.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 7
- Issue
- 4
- Pages
- 261-266
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W2131419480
- Cited by
- 283
- References
- 0
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Risau, W., Drexler, H., Mironov, V., Smits, A., Siegbahn, A., Funa, K., & Heldin, C.-H. (1992). Platelet-Derived Growth Factor is Angiogenic In Vivo. Growth Factors. https://doi.org/10.3109/08977199209046408
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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