Growth/Differentiation Factor-10: A New Member of the Transforming Growth Factor-β Superfamily Related to Bone Morphogenetic Protein-3
Abstract
We have identified a new member of the transforming growth factor-beta (TGF-beta) superfamily, growth/differentiation factor-10 (GDF-10), which is highly related to bone morphogenetic protein-3 (BMP-3). The nucleotide sequence of GDF-10 encodes a predicted protein of 476 amino acids with a molecular weight of approximately 52,000. The GDF-10 polypeptide contains a potential signal sequence for secretion, a putative RXXR proteolytic processing site, and a carboxy-terminal domain with considerable homology to other known members of the TGF-beta superfamily. In the mature carboxy-terminal domain GDF-10 is more homologous to BMP-3 (83% amino acid sequence identity) than to any other previously identified TGF-beta family member. GDF-10 also shows significant homology to BMP-3 (approximately 30% amino acid sequence identity) in the pro- region of the molecule. Based on these sequence comparisons, GDF-10 and BMP-3 define a new subgroup within the larger TGF-beta superfamily. By Northern analysis, GDF-10 mRNA was detected primarily in murine uterus, adipose tissue, and brain and to a lesser extent in liver and spleen. In addition, GDF-10 mRNA was present in both neonatal and adult bone samples, with higher levels being detected in calvaria than in long bone. These results suggest that GDF10 may play multiple roles in regulating cell differentiation events, including those involved in skeletal morphogenesis. Gdf10 was mapped to the proximal region of mouse chromosome 14 close to a reg…
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GDF10 is a divergent member of the bone morphogenetic protein (BMP)/transforming growth factor-β (TGFβ) superfamily.
“GDF10 is a divergent member of the bone morphogenetic protein (BMP)/transforming growth factor-β (TGFβ) superfamily11–14”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [11]
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References 50 · Cited by 104
- Authors
- Cunningham, N. S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Reddi, A. H., & Lee, S.-J.
- Affiliations
- Johns Hopkins University (US)
- Houston Methodist (US)
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 1995-01
- Volume
- 12
- Issue
- 2
- Pages
- 99-109
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W1978912394
- Cited by
- 104
- References
- 50
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 3 · 2013: 4
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Factors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01co074101-034, 5r01hd030740-04)
- National Cancer Institute (N01 CO-74101, CA58236, P50CA058236)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD30740)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- BMP3, TGF-beta superfamily, protein homology, skeletal morphogenesis, mouse chromosome 14, cell differentiation
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Female, Growth Substances, Humans, Molecular Sequence Data, Proteins, Tissue Distribution, Uterus, Gene Expression, Transforming Growth Factor beta, Sequence Homology, Sequence Analysis, DNA, DNA, Complementary, Bone Morphogenetic Proteins, Mice, Bone Morphogenetic Protein 3, Growth Differentiation Factor 10
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