Cushing’s syndrome in pregnancy
Abstract
Cushing's syndrome is a rare condition in the general population and is even less common during pregnancy with only a few cases reported in literature. The diagnosis of Cushing's syndrome may be difficult during pregnancy because the typical features of the disorder and pregnancy may overlap. However, Cushing's syndrome results in increased fetal and maternal complications, and diagnosis and treatment are critical. This report describes a case of 26-year-old female at the 19th week of pregnancy with symptoms and signs of hypercortisolism, where ACTH-independent Cushing's syndrome was diagnosed and treated by robotic laparoscopic adrenalectomy at the 21th week of gestation.
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In contrast to nonpregnant patients, the predominant etiology of CS in pregnant patients is adrenal adenomas, found in 40% to 60% of cases.
“In contrast to nonpregnant patients, the predominant etiology of CS in pregnant patients is adrenal adenomas, found in 40% to 60% of cases (90, 91).”
From Approach to the Patient: Diagnosis of Cushing Syndrome (2022) · cites this paper as [91]
Cites
Cushing’s Syndrome during Pregnancy: Personal Experience and Review of the Literature
Lindsay, J. R., Jonklaas, J., Oldfield, E. H., & Nieman, L. K. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2361 · Cited by 343 · cited 2× · see citing works
“To date, only a few cases have been reported in literature [1,2].”
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Hormonal Effects on Hair Follicles
Grymowicz, M., Rudnicka, E., Podfigurna, A., Napierała, P., Smolarczyk, R., Smolarczyk, K., & Męczekalski, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155342 · Cited by 213 · see citing works
Approach to the Patient: Diagnosis of Cushing Syndrome
Savas, M., Mehta, S., Agrawal, N., van Rossum, E. F. C., & Feelders, R. A. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac492 · Cited by 91 · see citing works
Surgery for Cushing's disease in pregnancy: our experience and a literature review.
Jolly, K., Darr, A., Arlt, W., Ahmed, S., & Karavitaki, N. (2019) · Annals of the Royal College of Surgeons of England · doi:10.1308/rcsann.2018.0175 · Cited by 18
Adrenal disorders in pregnancy, labour and postpartum – an overview
Manoharan, M., Sinha, P., & Sibtain, S. (2020) · Journal of Obstetrics and Gynaecology Research · doi:10.1080/01443615.2019.1648395 · Cited by 17 · see citing works
Surgical treatment of adrenal tumors during pregnancy
Bartz-Kurycki, M. A., Dream, S. Y., & Wang, T. S. (2022) · Reviews in Endocrine & Metabolic Disorders · doi:10.1007/s11154-022-09744-7 · Cited by 5 · see citing works
Robotic adrenalectomy for functional adenoma in second trimester treats worsening hypertension.
Capella, C., Chandrasekar, T., Counsilman, M., Sebastiano, C., Lallas, C., & Al-Kouatly, H. (2020) · Urology · doi:10.1016/j.urology.2020.04.077 · Cited by 3
“9 described a healthy neonate that did not need glucocorticoid replacement during the neonatal period.(5) These reported cases demonstrate the utility of robotic adrenalectomy in pregnancy, especially due to the maternal-fetal complications associated with untreated adrenal disease.”
BackgroundMethodCushing’s syndrome and pregnancy: diagnostic, treatment and management tactics
Golounina, O., Pavlova, M. G., Gronskaya, S. A., Казначеева, Т. В., Dzeranova, L., Belaya, J. E., & Fadeev, V. (2021) · Rossiiskii vestnik akushera-ginekologa · doi:10.17116/rosakush2021210515 · Cited by 2 · see citing works
A report of recurring pregnancy-induced Cushing's syndrome
Niafar, M., Bahrami, A., Ghorbani, F., Aghamohammadzadeh, N., Sadra, V., & Djalal, N. N. (2020) · Journal of Emergency Medicine Case Reports · doi:10.33706/jemcr.633840 · Cited by 1
Lirov, R., & Gauger, P. G. (2018) · Springer eBooks · doi:10.1007/978-981-10-1124-5_26 · Cited by 1 · see citing works
Cushing’s Syndrome in a Pregnant Woman
Nasrabadi, M., Mirarmandehi, S. B., & Roostaee, Z. (2017) · doi:10.29252/sjrm.2.2.85
Endogenous hypercortisolism in pregnant women
Yukina, M., Chernova, M. O., Belaya, Z., Troshina, E., Platonova, N., & Beltsevich, D. (2022) · Rossiiskii vestnik akushera-ginekologa · doi:10.17116/rosakush20222202147
- Authors
- Nassi, R., Ladu, C., Vezzosi, C., & Mannelli, M.
- Affiliations
- Ospedale San Donato (IT)
- University of Florence (IT)
- Corresponding author
- Ladu, Cristina
- ORCID
- Mannelli, Massimo
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2014-11-28
- Volume
- 31
- Issue
- 2
- Pages
- 102-104
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2053680016
- Cited by
- 16
- References
- 0
- Citations by year
- 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- Cushing's syndrome, pregnancy, ACTH-independent Cushing's syndrome, hypercortisolism, adrenal incidentaloma, fetal complications, maternal complications
- MeSH terms
- Adrenalectomy, Adult, Cushing Syndrome, Female, Humans, Pregnancy, Pregnancy Complications
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