Platelet to lymphocyte ratio as a prognostic marker in primary percutaneous coronary intervention
Abstract
We assessed the prognostic value of the platelet to lymphocyte ratio (PLR) in primary percutaneous coronary intervention (pPCI). Patients (n = 440) with acute myocardial infarction (AMI) who underwent pPCI were divided into 2 groups: low PLR (<137) and high PLR (>137). "Thrombolysis In Myocardial Infarction" (TIMI) flow grades and Syntax scores (SXS) were calculated from initial angiograms. In-hospital mortality rate and cardiac adverse events were obtained from medical records. Patients with high PLR had more no-reflow, higher SXS and higher mortality rate (p < 0.001, p < 0.001 and p = 0.008, respectively). In receiver operating characteristic curve analysis, high PLR predicted development of no-reflow (specificity 71% and sensitivity 85%), SXS>22 (specificity 52% and sensitivity 61%) and adverse events (specificity 67% and sensitivity 63%). In multivariate regression analysis, PLR was an independent risk factor for no-reflow, SXS>22 and in-hospital adverse events. In addition to PLR, we present the relationship between mean platelet volume, red cell distribution width and neutrophil to lymphocyte ratio and no-reflow, SXS and in-hospital adverse events.
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Patients with high PLR values (>137) had a greater incidence of the "no-reflow" phenomenon and mortality, as well as higher Syntax score values, indicative of a more severe and complex coronary disease.
“Patients with high PLR values had a greater incidence of the “no-reflow” phenomenon and mortality, as well as higher Syntax score values, indicative of a more severe and complex coronary disease [33].”
From Residual Cardiovascular Risk: Role of Remnants Cholesterol, Monocyte/HDL Ratio and Lipoprotein Ratios on Personalized Cardiovascular Prevention (2024) · cites this paper as [33]
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Ndrepepa, G., Tiroch, K., Fusaro, M., Keta, D., Seyfarth, M., Byrne, R. A., Pache, J., Alger, P., Mehilli, J., Schömig, A., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.054 · Cited by 475 · see citing works
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Sucato, V., Comparato, F., Ortello, A., Galassi, A. R., & Novo, G. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14050460 · Cited by 12 · see citing works
“Patients with high PLR values had a greater incidence of the “ no-reflow ” phenomenon and mortality, as well as higher Syntax score values, indicative of a more severe and complex coronary disease [33].”
Background
- Authors
- Ayça, B., Akin, F., Çelik, Ö., Yüksel, Y., Öztürk, D., Tekiner, F., Çetin, Ş., Okuyan, E., & Dinçkal M, H.
- Affiliations
- Bağcılar Eğitim ve Araştırma Hastanesi (TR)
- ,
- Corresponding author
- Ayça, Burak
- Venue
- Platelets
- Publisher
- Informa UK Limited
- Published
- 2014-10-28
- Volume
- 26
- Issue
- 7
- Pages
- 638-644
- ISSN
- 0953-7104 (ISSN-L)
- 1369-1635
- OpenAlex
- W2152630018
- Cited by
- 52
- References
- 1
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 12 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Platelets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Keywords
- platelet-to-lymphocyte ratio, primary percutaneous coronary intervention, acute myocardial infarction, no-reflow phenomenon, SYNTAX score, in-hospital mortality, prognostic factors, mean platelet volume, red cell distribution width, neutrophil-to-lymphocyte ratio, TIMI flow
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Hospitalization, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Count, Prognosis, Retrospective Studies, ROC Curve, Biomarkers, Lymphocyte Count, Percutaneous Coronary Intervention
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