Cortisol response to psychosocial stress during a depressive episode and remission
Open accessAbstract
This study compared cortisol responses to a standardized psychosocial stressor during a major depressive episode (MDE) and again during remission in adolescents and young adults. Twenty-six individuals with no personal or family history of a major psychiatric disorder (NC) and 24 individuals with a diagnosis of major depressive disorder (MDD) at Time 1 participated in the study. The MDD group showed robust cortisol responses during their index episode and after recovery. In contrast, the NC group showed habituation to the repeated psychosocial stressor, as evident in a flatter cortisol response profile at Time 2. Within the MDD group, net peak cortisol during the first stress test was positively associated with the duration of the index MDE and negatively associated with the total duration of all MDEs. Whereas summary indices of cortisol responses were relatively stable across repeated stress tasks within the MDD group, this was not the case for NC. Results demonstrate that cortisol responses fail to habituate to repeated psychosocial stress during recovery from an MDE and could reflect a trait-like marker of risk for recurrence.
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Cortisol responses to laboratory psychosocial stress in major depressive disorder are inconsistent, with some studies reporting hyperreactivity and others hyporeactivity.
“cortisol responses to a laboratory psychosocial stressor in MDD are mixed, with some showing cortisol hyperreactivity, while others hyporeactivity (75,76).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [76]
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References 36 · Cited by 34
Research works printed but not linked: 1
- First MB Spitzer RL Gibbon M Williams JBW User’s guide for the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) - Clinician Version Washington, DC American Psychiatric Press 1997
- Authors
- Morris, M. C., & Rao, U.
- Affiliations
- Meharry Medical College (US)
- Vanderbilt University (US)
- Corresponding author
- Morris, Matthew C.
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2013-11-20
- Volume
- 17
- Issue
- 1
- Pages
- 51-58
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- PMC
- PMC3920542
- OpenAlex
- W2029463250
- Cited by
- 34
- References
- 36
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 5 · 2016: 1 · 2015: 5 · 2014: 3
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000445)
- National Institute of Mental Health (K01MH101403, R01MH062464, R01MH068391)
- National Institute on Drug Abuse (R01DA015131, R01DA017804, R01DA014037, R01DA017805)
- National Center for Research Resources (G12RR003032, U54RR026140, UL1 RR024975/TR000445, UL1RR024975)
- National Center for Advancing Translational Sciences
- National Institute on Minority Health and Health Disparities (G12 RR003032/MD007586, U54MD007593, U54 RR026140/MD007593, G12MD007586, U54MD007586)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- cortisol, psychosocial stress, major depressive episode, remission, major depressive disorder, adolescents, young adults, stress habituation, recurrence risk, trait markers
- MeSH terms
- Adolescent, Major Depressive Disorder, Female, Habituation, Psychophysiologic, Humans, Hydrocortisone, Male, Stress, Psychological, Young Adult
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