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Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential

Open access
Groenewald, Marizeth, Boekhout, Teun, Neuvéglise, Cécile, Gaillardin, Claude, van Dijck, Piet W. M., Wyss, Markus·2014·Critical Reviews in Microbiology

Abstract

Yarrowia lipolytica has been developed as a production host for a large variety of biotechnological applications. Efficacy and safety studies have demonstrated the safe use of Yarrowia-derived products containing significant proportions of Yarrowia biomass (as for DuPont's eicosapentaenoic acid-rich oil) or with the yeast itself as the final product (as for British Petroleum's single-cell protein product). The natural occurrence of the species in food, particularly cheese, other dairy products and meat, is a further argument supporting its safety. The species causes rare opportunistic infections in severely immunocompromised or otherwise seriously ill people with other underlying diseases or conditions. The infections can be treated effectively by the use of regular antifungal drugs, and in some cases even disappeared spontaneously. Based on our assessment, we conclude that Y. lipolytica is a "safe-to-use" organism.

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Metadata

Authors
Groenewald, M., Boekhout, T., Neuvéglise, C., Gaillardin, C., van Dijck, P. W. M., & Wyss, M.
Venue
Critical Reviews in Microbiology
Published
2013-03-14
Volume
40
Issue
3
Pages
187-206
ISSN
  • 1040-841X (ISSN-L)
  • 1549-7828
OpenAlex
W2056077497
Cited by
498
References
2
FWCI
11.03
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential. https://app.cochat.ai/papers/10.3109/1040841x.2013.770386
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Groenewald, M., Boekhout, T., Neuvéglise, C., Gaillardin, C., van Dijck, P. W. M., & Wyss, M. (2014). Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential. Critical Reviews in Microbiology. https://doi.org/10.3109/1040841x.2013.770386

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.