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pH-Dependent Processes in Protein
Abstract
Recent improvements in the understanding of electrostatic interactions in proteins serve as a focus for the general topic of pH-dependent processes in proteins. The general importance of pH-dependent processes is first set out in terms of hydrogen ion equilibria, stability, ligand interactions, assembly, dynamics, and events in related molecular systems. The development of various theoretical treatments includes various formalisms in addition to the solvent interface model developed by Shire et al. as an extension of the Tanford-Kirkwood treatment. A number of detailed applications of the model are presented and future potentialities are sketched.
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Citations
Cited by
On the calculation of p Kas in proteins
Yang, A., Gunner, M. R., Sampogna, R., Sharp, K., & Honig, B. (1993) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340150304 · Cited by 508
Protein Ionizable Groups: pK Values and Their Contribution to Protein Stability and Solubility
Pace, C. N., Grimsley, G. R., & Scholtz, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800080200 · Cited by 461
pK values of the ionizable groups of proteins
Thurlkill, R. L., Grimsley, G. R., Scholtz, J. M., & Pace, C. N. (2006) · Protein Science · doi:10.1110/ps.051840806 · Cited by 369
Treatment of electrostatic effects in macromolecular modeling
Harvey, S. C. (1989) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340050109 · Cited by 349
High Apparent Dielectric Constants in the Interior of a Protein Reflect Water Penetration
Dwyer, J. J., Gittis, A. G., Karp, D. A., Lattman, E. E., Spencer, D. S., Stites, W. E., & García-Moreno E., B. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76411-3 · Cited by 324
Metadata
- Authors
- Matthew, J. B., Gurd, F. R. N., Garcia-Moreno, B. E., Flanagan, M. A., March, K. L., & Shire, S. J.
- Venue
- Critical Reviews in Biochemistry
- Publisher
- Informa UK Limited
- Published
- 1985-01
- Volume
- 18
- Issue
- 2
- Pages
- 91-197
- ISSN
- 0045-6411 (ISSN-L)
- 1040-8355
- OpenAlex
- W2212681463
- Cited by
- 182
- References
- 0
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Matthew, J. B., Gurd, F. R. N., Garcia-Moreno, B. E., Flanagan, M. A., March, K. L., & Shire, S. J. (1985). pH-Dependent Processes in Protein. Critical Reviews in Biochemistry. https://doi.org/10.3109/10409238509085133
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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