Central sensitivity syndromes: An overview
Abstract
.Objective: To discuss the concept of central sensitivity syndromes [CSS] and its significance. An overview of the current literature was incorporated with the author's insight and views.Findings: A good number of disorders that show clinical overlap with fibromyalgia syndrome also meet the Yunus criteria for CSS. These criteria are based essentially on two components: mutual associations and evidence for central sensitization [CS] among them. While CS is likely to be the common binding glue for the CSS diseases, other pathophysiological mechanisms may also be involved. CSS is based on a biopsychosocial model.Conclusions: The CSS seems to be an important concept for future research and medical education, as well as patient care.
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Interstitial cystitis is considered a central sensitization syndrome.
“Accordingly, and due also to the similarities of the symptoms with CSS, IC is also considered a CSS [9,49].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [9]
There is wide agreement that fibromyalgia syndrome should be considered a central pain sensitization syndrome.
“Although it is not clear how these physiologic alterations are generated, there is a wide agreement that FMS should be considered as a CPSS [9,10,11,32,33,34].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [9]
Central pain sensitization explains the occurrence and maintenance of spontaneous pain, as well as hypersensitivity to innocuous (allodynia) or low-intensity (hyperalgesia) stimulation in central pain sensitization syndromes.
“CPS explains the occurrence of spontaneous pain, and maintenance thereof, as well as hypersensitivity to innocuous (allodynia) or low-intensity (hyperalgesia) stimulation in the so-called central pain sensitization syndromes (CPSS) [2,8,9].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [9]
According to Yunus's classification, central sensitization syndromes that involve the experience of chronic pain can be considered central pain sensitization syndromes.
“According to the classification developed by M. B. Yunus on central sensitization syndromes (2007; 2009; 2015), those that involve the experience of chronic pain could be considered as CPSS [9,10,11].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [9]
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References 69 · Cited by 29
- Authors
- Yunus, M. B.
- Affiliations
- Peoria campus of the University of Illinois System (US)
- Corresponding author
- Yunus, Muhammad B.
- Venue
- Journal of Musculoskeletal Pain
- Publisher
- Informa UK Limited
- Published
- 2009-11-12
- Volume
- 17
- Issue
- 4
- Pages
- 400-408
- ISSN
- 1058-2452 (ISSN-L)
- 1540-7012
- OpenAlex
- W2170614673
- Cited by
- 29
- References
- 69
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Musculoskeletal Pain (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- central sensitivity syndromes, central sensitization, fibromyalgia, biopsychosocial model, pathophysiology, chronic pain
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