The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Renin-Angiotensin-Aldosterone System: A Long-Term Follow-Up Study in 17α-Hydroxylase Deficiency Syndrome (17OHDS)
Abstract
We studied the mineralocorticoid pattern in 4 patients with 17OHD during long-term glucocorticoid treatment. We observed reduction of BP, normalization of K levels, a gradual increase in PRA and in urinary Aldosterone (ALDO); a normal response of plasma ALDO to ACTH and to angiotensin II was present only in one case. We observed a prompt decrease of mineralocorticoid hormones, normalized by long-term therapy only in one case. Discontinuation of treatment induced an increase of ALDO that became suppressed in late off-treatment. Thus, glucocorticoid treatment decreases abnormal steroid levels and activates zona glomerulosa (ZG) function, even if it may take years for ALDO to normalize. Brief discontinuation of therapy induces a surge in ALDO levels, revealing no biosynthetic defect in ZG, while in late off-treatment mineralocorticoids seem to come exclusively from zona fasciculata.
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When P450c17 deficiency is treated with glucocorticoids, DOC secretion is suppressed and plasma renin activity and aldosterone concentrations rise to normal.
“When P450c17 deficiency is treated with glucocorticoids, DOC secretion is suppressed and plasma renin activity and aldosterone concentrations rise to normal (263).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [263]
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Cites
17-Hydroxylation deficiency in man
Biglieri, E. G., Herron, M. A., & Brust, N. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105499 · Cited by 561
Male pseudohermaphroditism due to 17α-hydroxylase deficiency
New, M. I. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106412 · Cited by 211
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The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458
Metadata
- Authors
- Scaroni, C., Opocher, G., & Mantero, F.
- Affiliations
- University of Padua (IT)
- Venue
- Clinical and Experimental Hypertension. Part A: Theory and Practice
- Publisher
- Informa UK Limited
- Published
- 1986-01
- Volume
- 8
- Issue
- 4-5
- Pages
- 773-780
- ISSN
- 0148-3927 (ISSN-L)
- 0730-0077
- OpenAlex
- W2156754587
- Cited by
- 13
- References
- 2
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- renin-angiotensin-aldosterone system, mineralocorticoid activity, glucocorticoid therapy, plasma aldosterone, plasma renin activity, potassium concentration, zona glomerulosa, zona fasciculata, aldosterone biosynthesis, treatment discontinuation, hypertension
- MeSH terms
- Adolescent, Adrenal Glands, Adrenal Hyperplasia, Congenital, Adult, Aldosterone, Female, Glucocorticoids, Humans, Hypertension, Male, Mineralocorticoids, Renin, Renin-Angiotensin System, Steroid Hydroxylases, Syndrome
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