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5-HT Receptors: Subtypes and Second Messengers
Abstract
Our knowledge about 5-HT (serotonin, 5-hydroxytryptamine) receptors has gained significantly over the recent few years. The discovery of selective ligands and the use of new techniques have led to a significant increase in the number of recognised receptors subtypes. The present status of awareness is largely related to the use of radioligand binding studies, autoradiography, second messenger analysis and more recently, molecular biological techniques. Three main families of 5-HT receptors, of which subtypes have been described, are now accepted. This heterogeneity is further substantiated by the cloning of the cDNA's of three different 5-HT receptors. This article reviews some of the recent developments which led to the characterisation of 5-HT receptor subtypes.
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Cited by
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Vollenweider, F. X., Vollenweider-Scherpenhuyzen, M. F. I., Bäbler, A., Vogel, H., & Hell, D. (1998) · NeuroReport · doi:10.1097/00001756-199812010-00024 · Cited by 1,018
Artigas, F., Romero, L., de Montigny, C., & Blier, P. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10037-0 · Cited by 655
Autoregulation of Serotonin Neurons: Role in Antidepressant Drug Action
Piñeyro, G., & Blier, P. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01417-0 · Cited by 537
5HT drugs in animal models of anxiety
Handley, S. L., & McBlane, J. W. (1993) · Psychopharmacology · doi:10.1007/bf02247358 · Cited by 253
Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors
Smith, R. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00110-5 · Cited by 147
Metadata
- Authors
- Hoyer, D., & Schoeffter, P.
- Venue
- Journal of Receptor Research
- Publisher
- Informa UK Limited
- Published
- 1991-01
- Volume
- 11
- Issue
- 1-4
- Pages
- 197-214
- ISSN
- 0197-5110 (ISSN-L)
- OpenAlex
- W2011952312
- Cited by
- 201
- References
- 0
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
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