The neonatal testosterone surge: A comparative study
Abstract
In the rat an abrupt discharge of testicular testosterone in the newborn male figures prominently in the development of mechanisms controlling gonadotropin secretion, sexual behavior, and also promotes the functional differentiation of the accessory sex glands. In this study we detail the temporal characteristics of this surge in the rat, and we provide comparative data documenting a similar surge-like appearance of testosterone in neonatal male mice, recently foaled male horses, and newborn human infants. Although the physiological and behavioral significance of this phenomenon for species other than the rat remains to be determined, the apparently ubiquitous appearance of the neonatal testosterone surge suggests that it may be of special significance in the sexual differentiation of many mammalian species.
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In mammals, the differentiated testis produces a prenatal (in human and nonhuman primates) or neonatal (in rodents) testosterone surge that is critical to masculinize the organism.
“To achieve a male-specific brain, the differentiated testis produces a prenatal (in human and nonhuman primates) or neonatal (in rodents) testosterone surge that is critical to masculinize the organism [58].”
From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [58]
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Sex differences in metabolic homeostasis, diabetes, and obesity
Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626 · see citing works
“natal (in rodents) testosterone surge that is critical to masculinize the organism [58].”
BackgroundTata, B., Mimouni, N. E. H., Barbotin, A.-L., Malone, S. A., Loyens, A., Pigny, P., Dewailly, D., Catteau-Jonard, S., Sundström-Poromaa, I., Piltonen, T. T., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0035-5 · Cited by 434 · see citing works
Early-Life Exposure to Testosterone Programs the Hypothalamic Melanocortin System
Nohara, K., Zhang, Y., Waraich, R. S., Laque, A., Tiano, J. P., Tong, J., Münzberg, H., & Mauvais-Jarvis, F. (2011) · Endocrinology · doi:10.1210/en.2010-1288 · Cited by 120 · see citing works
Borges, C. D. S., Dias, A. F. M. G., Silva, P. V., Rosa, J. L., Guerra, M. T., Silva, R. F., Kiguti, L. R. A., Pupo, A. S., & Kempinas, W. D. G. (2017) · Toxicology · doi:10.1016/j.tox.2016.04.005 · Cited by 35 · see citing works
Effects of prenatal hydrocortisone acetate exposure on fertility and sexual behavior in male rats
Pereira, O. C. M., Arena, A. C., Yasuhara, F., & Kempinas, W. G. (2003) · Regulatory Toxicology and Pharmacology · doi:10.1016/s0273-2300(03)00046-1 · Cited by 33 · see citing works
Sexual differentiation of neural mechanisms of stress sensitivity during puberty
Wright, E. C., Luo, P. X., Zakharenkov, H. C., Serna Godoy, A., Lake, A. A., Prince, Z. D., Sekar, S., Culkin, H. I., Ramirez, A. V., Dwyer, T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306475120 · Cited by 34 · see citing works
Reproductive disorders in female rats after prenatal exposure to betamethasone
Borges, C. S., Pacheco, T. L., Guerra, M. T., Barros, A. L., Silva, P. V., Missassi, G., da Silva, K. P., Anselmo‐Franci, J. A., Pupo, A. S., & Kempinas, W. D. G. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3457 · Cited by 25 · see citing works
Borges, C. S., Dias, A. F. M. G., Rosa, J. L., Silva, P. V., Silva, R. F., Barros, A. L., Sanabria, M., Guerra, M. T., Gregory, M., Cyr, D. G., et al. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.05.021 · Cited by 21 · see citing works
Pereira, O. C. M., & Piffer, R. C. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.04.001 · Cited by 18 · see citing works
- Authors
- Corbier, P., Edwards, D. A., & Roffi, J.
- Affiliations
- Université Paris-Sud (FR)
- ORCID
- Edwards, D. A.
- Venue
- Archives Internationales de Physiologie, de Biochimie et de Biophysique
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 100
- Issue
- 2
- Pages
- 127-131
- ISSN
- 0778-3124 (ISSN-L)
- OpenAlex
- W2020224460
- Cited by
- 217
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 9 · 2023: 11 · 2022: 7 · 2021: 9 · 2020: 6 · 2019: 12 · 2018: 16 · 2017: 15 · 2016: 10 · 2015: 10 · 2014: 11 · 2013: 6 · 2012: 7
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- neonatal testosterone, gonadotropin secretion, sexual differentiation, accessory sex glands, sexual behavior, rats, mice, foals, infants, comparative physiology
- MeSH terms
- Animals, Animals, Newborn, Female, Horses, Humans, Infant, Newborn, Kinetics, Male, Mice, Inbred C57BL, Species Specificity, Testosterone, Mice, Rats
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