Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil
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This study investigated some pharmacological properties of virgin coconut oil (VCO), the natural pure oil from coconut [Cocos nucifera Linn (Palmae)] milk, which was prepared without using chemical or high-heat treatment. The anti-inflammatory, analgesic, and antipyretic effects of VCO were assessed. In acute inflammatory models, VCO showed moderate anti-inflammatory effects on ethyl phenylpropiolate-induced ear edema in rats, and carrageenin- and arachidonic acid-induced paw edema. VCO exhibited an inhibitory effect on chronic inflammation by reducing the transudative weight, granuloma formation, and serum alkaline phosphatase activity. VCO also showed a moderate analgesic effect on the acetic acid-induced writhing response as well as an antipyretic effect in yeast-induced hyperthermia. The results obtained suggest anti-inflammatory, analgesic, and antipyretic properties of VCO.
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VCO significantly reduced arachidonic acid-induced paw edema and ethyl phenylpropionate-induced ear edema in rats.
“Intahphuak et al. [107] reported that VCO significantly reduced arachidonic acid-induced paw edema and ethyl phenylpropionate-induced ear edema in rats, indicating its efficacy in acute inflammatory responses.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [107]
VCO exhibited moderate analgesic and antipyretic effects, associated with decreased serum alkaline phosphatase, reduced transudative weight, and inhibition of granuloma formation.
“Additionally, VCO exhibited moderate analgesic and antipyretic effects, which were associated with decreased serum alkaline phosphatase, reduced transudative weight, and inhibition of granuloma formation.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [107]
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References 30 · Cited by 209
- Authors
- Intahphuak, S., Khonsung, P., & Panthong, A.
- Affiliations
- Payap University (TH)
- Chiang Mai University (TH)
- Corresponding author
- Intahphuak, S.
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2009-12-29
- Volume
- 48
- Issue
- 2
- Pages
- 151-157
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2128731431
- Cited by
- 209
- References
- 30
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 19 · 2023: 23 · 2022: 24 · 2021: 24 · 2020: 20 · 2019: 18 · 2018: 15 · 2017: 14 · 2016: 5 · 2015: 13 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmaceutical Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chiang Mai University
- Thailand Research Fund
- Commission on Higher Education
- Faculty of Medicine, Chiang Mai University
- Division of Chemistry
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- virgin coconut oil, anti-inflammatory activity, analgesic activity, antipyretic activity, Cocos nucifera, ear edema, paw edema, chronic inflammation, granuloma formation, alkaline phosphatase, acetic acid-induced writhing
- MeSH terms
- Coconut Oil, Alkaline Phosphatase, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cocos, Edema, Fatty Acids, Fever, Fruit, Granuloma, Hyperalgesia, Hyperthermia, Induced, Male, Phytotherapy, Plant Oils, Pyrogens, Time Factors, Rats, Sprague-Dawley, Mice, Rats, Antipyretics
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