No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy
Open accessAbstract
OBJECTIVE: The aim of the present study was to evaluate the possible effects of Q10 and selenium supplementation on statin-induced myopathy (SIM), both for subjective symptoms and muscle function. DESIGN: Patients (N = 43) who had experienced previous or ongoing SIM on atorvastatin therapy were recruited. Following a 6-week washout period during which no statins were administered, the patients were re-challenged with 10 mg of atorvastatin. Patients (N = 41) who experienced SIM continued the atorvastatin treatment and were in addition randomized to receive 12 weeks supplement of 400 mg Q10 and 200 μg selenium per day or a matching double placebo. SIM was assessed using 3 validated symptom questionnaires, and a muscle function test was performed at the beginning and at the end of the study. RESULTS: The patients receiving the active supplement experienced significant increases in their serum Q10 and selenium concentrations compared with the group receiving placebo. No statistically significant differences in symptom questionnaire scores or muscle function tests were revealed between the groups. CONCLUSIONS: Despite substantial increases in the serum Q10 and selenium levels following the oral supplementation, this study revealed no significant effects on SIM compared with the placebo.
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A number of randomised controlled trials have reported that CoQ10 reduces statin-associated muscle symptoms, while others have failed to demonstrate a benefit.
“A number of these RCTs have reported that CoQ10 reduces SAMS [4-7], while other have failed to demonstrate a benefit [8-12].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [10]
Some studies included in previous meta-analyses were excluded from this review due to lack of a placebo control or due to treatment with another active substance.
“As a result, some studies included in previous meta-analyses were excluded due to the lack of a placebo control or due to the treatment with another active substance [4,7,10].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [10]
Randomized controlled trial results demonstrated that statins reduced circulating CoQ10 by 16% to 54%.
“The RCT results15, 17, 24, 25, 26, 27, 28 demonstrated that statins reduced circulating CoQ10 by 16% to 54%”
From Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials (2018) · cites this paper as [15]
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References 25 · Cited by 53
Research works printed but not linked: 3
- Thompson PD , Clarkson P , Karas RH . Statin-associated 1. myopathy . JAMA. 2003 ; 289 : 1681 -90 .
- Quinzii CM , DiMauro S , Hirano M . Human coenzyme Q10 6. defi ciency . Neurochem Res. 2007 ; 32 : 723 -7 .
- Br ä hler E , Scheer J . 1983 . Der Giessener Beschwerdebogen 17. (GBB). Bern: Huber . Vassend O , Lian L , Andersen HT . [Norwegian version of 18. NEOPersonality Inventory, Symptom Checklist 90 Revised, and Giessen Subjective Complaints List] . Tidsskr NorP- sykologforen . 1992 ; 29 : 1150 -60 .
- Authors
- Bogsrud, M. P., Langslet, G., Ose, L., Arnesen, K.-E., Sm stuen, M. C., Malt, U. F., Woldseth, B., & Retterstøl, K.
- Affiliations
- Oslo University Hospital (NO)
- National Resource Center for Late Effects, Oslo University Hospital, Rikshospitalet, Oslo, Norway
- Corresponding author
- Bogsrud, Martin Prøven
- Venue
- Scandinavian Cardiovascular Journal
- Publisher
- Informa UK Limited
- Published
- 2013-01-10
- Volume
- 47
- Issue
- 2
- Pages
- 80-87
- ISSN
- 1401-7431 (ISSN-L)
- 1651-2006
- OpenAlex
- W1969896801
- Cited by
- 53
- References
- 25
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 1
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Scandinavian Cardiovascular Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- statin-induced myopathy, atorvastatin, coenzyme Q10, selenium supplementation, statin rechallenge, muscle function, muscle symptoms, statin adverse effects
- MeSH terms
- Atorvastatin, Adult, Aged, Antioxidants, Double-Blind Method, Drug Therapy, Combination, Female, Heptanoic Acids, Humans, Male, Middle Aged, Muscular Diseases, Prospective Studies, Pyrroles, Surveys and Questionnaires, Selenium, Ubiquinone, Vitamins, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Dietary Supplements
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