Neural response during anticipation of monetary loss is elevated in adult attention deficit hyperactivity disorder
Open accessAbstract
OBJECTIVES: Risky behaviour seriously impacts the life of adult patients with attention deficit hyperactivity disorder (ADHD). Such behaviours have often been attributed to their exaggerated reward seeking, but dysfunctional anticipation of negative outcomes might also play a role. METHODS: The present study compared adult patients with ADHD (n = 28) with matched healthy controls (n = 28) during anticipation of monetary losses versus gains while undergoing functional magnetic resonance imaging (fMRI) and skin conductance recording. RESULTS: Skin conductance was higher during anticipation of losses compared to gains in both groups. Affective ratings of predictive cues did not differ between groups. ADHD patients showed increased activity in bilateral amygdalae, left anterior insula (region of interest analysis) and left temporal pole (whole brain analysis) compared to healthy controls during loss versus gain anticipation. In the ADHD group higher insula and temporal pole activations went along with more negative affective ratings. CONCLUSIONS: Neural correlates of loss anticipation are not blunted but rather increased in ADHD, possibly due to a life history of repeated failures and the respective environmental sanctions. Behavioural adaptations to such losses, however, might differentiate them from controls: future research should study whether negative affect might drive more risk seeking than risk avoidance.
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In response to monetary loss, one study found no differences in adults with childhood ADHD, while another found enhanced activation in 28 ADHD adults in temporal pole and limbic regions of amygdala and insula.
“In response to monetary loss, one study found no differences in adults with childhood ADHD (Stoy et al., 2011), while another found enhanced activation in 28 ADHD adults in temporal pole and limbic regions of amygdala and insula (Wilbertz et al., 2017).”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Wilbertz et al., 2017
Wilbertz et al. (2017) reported an increased neural response to monetary loss in adults with ADHD during a probabilistic monetary loss or gain paradigm, but did not find any group differences in SCR.
“In a later study (Wilbertz et al., 2017), the authors reported an increased neural response to monetary loss in adults with ADHD during a probabilistic monetary loss or gain paradigm, but did not find any group differences in SCR.”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Wilbertz et al., 2017
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References 76 · Cited by 18
- Authors
- Wilbertz, G., Delgado, M. R., Tebartz Van Elst, L., Maier, S., Philipsen, A., & Blechert, J.
- Affiliations
- University of Freiburg (DE)
- Rutgers, The State University of New Jersey (US)
- ,
- University Medical Center Freiburg (DE)
- Carl von Ossietzky Universität Oldenburg (DE)
- Center for Cognitive Neuroscience, University of Salzburg, Salzburg, Austria;
- Corresponding author
- Wilbertz, Gregor
- Venue
- The World Journal of Biological Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2015-12-22
- Volume
- 18
- Issue
- 4
- Pages
- 268-278
- ISSN
- 1562-2975 (ISSN-L)
- 1814-1412
- OpenAlex
- W2198575505
- Cited by
- 18
- References
- 76
- Citations by year
- 2023: 4 · 2021: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2014: 1
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- The World Journal of Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adult ADHD, loss anticipation, financial losses, risk-taking, amygdala, anterior insula, temporal pole, skin conductance, negative affect, reward seeking
- MeSH terms
- Adult, Amygdala, Attention Deficit Disorder with Hyperactivity, Cerebral Cortex, Female, Galvanic Skin Response, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reward, Anticipation, Psychological
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