The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Impact of silver nanoparticles on human cells: Effect of particle size
Abstract
This work investigated the cytotoxicities of three silver nanoparticles (SNPs) SNP-5, SNP-20 and SNP-50 with different sizes ( approximately 5 nm, approximately 20 nm and approximately 50 nm) using four human cell models (A549, SGC-7901, HepG2 and MCF-7). Endpoints included cell morphology, cell viability, cellular membrane integrity, oxidative stress and cell cycle progression. Observable deleterious effects on the cell morphologies and membrane integrity were induced by SNP-5 and SNP-20. SNPs elevated the ROS levels in cells and arrested the cells at S phase. Apoptosis occurred for 4-9% of the exposed cells. All these cellular responses as well as EC50 values were found to be size-dependent for the tested SNPs. Ultrastructural observations confirmed the presence of SNPs inside cells. Elemental analysis of silver in cells by ICP-MS showed that smaller nanoparticles enter cells more easily than larger ones, which may be the cause of higher toxic effects. The findings may assist in the design of SNP applications and provide insights into their toxicity.
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
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Silver nanoparticles: Synthesis, medical applications and biosafety
Xu, L., Wang, Y.-Y., Huang, J., Chen, C.-Y., Wang, Z.-X., & Xie, H. (2020) · Theranostics · doi:10.7150/thno.45413 · Cited by 1,315
Masters, E. A., Trombetta, R. P., de Mesy Bentley, K. L., Boyce, B. F., Gill, A. L., Gill, S. R., Nishitani, K., Ishikawa, M., Morita, Y., Ito, H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0061-z · Cited by 575
Big data and artificial intelligence modeling for drug discovery
Zhu, H. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023324 · Cited by 455
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Metadata
- Authors
- Liu, W., Wu, Y., Wang, C., Li, H. C., Wang, T., Liao, C. Y., Cui, L., Zhou, Q. F., Yan, B., & Jiang, G. B.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2010-05-14
- Volume
- 4
- Issue
- 3
- Pages
- 319-330
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W1991399962
- Cited by
- 505
- References
- 1
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, W., Wu, Y., Wang, C., Li, H. C., Wang, T., Liao, C. Y., Cui, L., Zhou, Q. F., Yan, B., & Jiang, G. B. (2010). Impact of silver nanoparticles on human cells: Effect of particle size. Nanotoxicology. https://doi.org/10.3109/17435390.2010.483745
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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