The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells
Open accessAbstract
Nanomaterials are increasingly used in various food applications. In particular, nanoparticulate amorphous SiO2 is already contained, e.g., in spices. Since intestinal dendritic cells (DC) could be critical targets for ingested particles, we compared the in vitro effects of amorphous silica nanoparticles with fine crystalline silica, and micron-sized with nano-sized TiO2 particles on DC. TiO2- and SiO2-nanoparticles, as well as crystalline silica led to an upregulation of MHC-II, CD80, and CD86 on DC. Furthermore, these particles activated the inflammasome, leading to significant IL-1β-secretion in wild-type (WT) but not Caspase-1- or NLRP3-deficient mice. Silica nanoparticles and crystalline silica induced apoptosis, while TiO2 nanoparticles led to enhanced production of reactive oxygen species (ROS). Since amorphous silica and TiO2 nanoparticles had strong effects on the activation-status of DC, we suggest that nanoparticles, used as food additives, should be intensively studied in vitro and in vivo, to ensure their safety for the consumer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Self-citationInnate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445
IL1β‐ and LPS‐induced serotonin secretion is increased in EC cells derived from Crohn’s disease
Kidd, M., Gustafsson, B. I., Drozdov, I., & Modlin, I. M. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01210.x · Cited by 130
Cited by
Amino-Functionalized Polystyrene Nanoparticles Activate the NLRP3 Inflammasome in Human Macrophages
Lunov, O., Syrovets, T., Loos, C., Nienhaus, G. U., Mailänder, V., Landfester, K., Rouis, M., & Simmet, T. (2011) · ACS Nano · doi:10.1021/nn203596e · Cited by 262
Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation
Silva, A. L., Peres, C., Conniot, J., Matos, A. I., Moura, L., Carreira, B., Sainz, V., Scomparin, A., Satchi-Fainaro, R., Préat, V., et al. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.09.003 · Cited by 95
Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo
Shi, Z., Niu, Y., Wang, Q., Shi, L., Guo, H., Liu, Y., Zhu, Y., Liu, S., Liu, C., Chen, X., et al. (2015) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2015.05.043 · Cited by 56
Hiroike, M., Sakabe, J., Kobayashi, M., Shimauchi, T., Ito, T., Hirakawa, S., Inoh, A., & Tokura, Y. (2013) · The Journal of Dermatology · doi:10.1111/1346-8138.12132 · Cited by 16
Metadata
- Authors
- Winter, M., Beer, H.-D., Hornung, V., Krämer, U., Schins, R. P. F., & Förster, I.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2010-09-16
- Volume
- 5
- Issue
- 3
- Pages
- 326-340
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W2034843771
- Cited by
- 194
- References
- 6
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells. https://app.cochat.ai/papers/10.3109/17435390.2010.506957
- The paper
- Winter, M., Beer, H.-D., Hornung, V., Krämer, U., Schins, R. P. F., & Förster, I. (2011). Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells. Nanotoxicology. https://doi.org/10.3109/17435390.2010.506957
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
