The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo ; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs
Abstract
Abstract Nickel, zinc, and copper oxide nanoparticles (NiONP, ZnONP, and CuONP) and their aqueous extracts (AEs) were applied to A549 lung epithelial cells to determine the cytotoxicity, IL-8 production, and activation of transcription factors. Nanoparticles (NPs) and their AEs were also instilled into rat lungs to evaluate acute and chronic inflammatory effects. In vitro AEs had specific effects; for example NiOAE had no effect and ZnOAE affected all parameters measured. NPs themselves all had cytotoxic effects but only ZnONP and CuONP impacted pro-inflammatory endpoints. The inflammatory cells in the BAL were also different from AEs and NPs with ZnONP and CuONP recruiting eosinophils and neutrophils whilst ZnOAE and CuOAE elicited only mild neutrophilic inflammation that had resolved by four weeks. NiONP recruited neutrophils only whilst NiOAE did not cause any inflammation. Understanding differences in the toxic role of the ionic components of metal oxide NPs will contribute to full hazard identification and characterisation.
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Cites
Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer size
Karlsson, H. L., Gustafsson, J., Cronholm, P., & Möller, L. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.03.014 · Cited by 949
Cited by
A review of mammalian toxicity of ZnO nanoparticles
Vandebriel, R., & De Jong, W. (2012) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s23932 · Cited by 494
Physicochemical characteristics of nanomaterials that affect pulmonary inflammation
Braakhuis, H. M., Park, M. V., Gosens, I., De Jong, W. H., & Cassee, F. R. (2014) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-11-18 · Cited by 358
Ivask, A., Juganson, K., Bondarenko, O., Mortimer, M., Aruoja, V., Kasemets, K., Blinova, I., Heinlaan, M., Slaveykova, V., & Kahru, A. (2014) · Nanotoxicology · doi:10.3109/17435390.2013.855831 · Cited by 332
Nanoparticles and innate immunity: new perspectives on host defence
Boraschi, D., Italiani, P., Palomba, R., Decuzzi, P., Duschl, A., Fadeel, B., & Moghimi, S. M. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.08.013 · Cited by 310
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Metadata
- Authors
- Cho, W.-S., Duffin, R., Poland, C. A., Duschl, A., Oostingh, G. J., MacNee, W., Bradley, M., Megson, I. L., & Donaldson, K.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2011-02-18
- Volume
- 6
- Issue
- 1
- Pages
- 22-35
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W2168611799
- Cited by
- 241
- References
- 1
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cho, W.-S., Duffin, R., Poland, C. A., Duschl, A., Oostingh, G. J., MacNee, W., Bradley, M., Megson, I. L., & Donaldson, K. (2012). Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo ; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs. Nanotoxicology. https://doi.org/10.3109/17435390.2011.552810
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