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Local injection of TGF-β increases the strength of tibial fractures in the rat
Open accessAbstract
The effect of Transforming Growth Factor beta (TGF-beta) administered locally around the fracture line of healing rat tibial fractures was investigated after 40 days of healing. TGF-beta in a dose of 4 ng or 40 ng was injected every second day during the healing period. The strength, stiffness, energy absorption and deflection of the fractures were measured in a materials-testing machine. Compared with placebo-treated animals, the ultimate load of the fractures increased in the group injected with 40 ng of TGF-beta, but not in those injected with 4 ng. TGF-beta induced a dose-dependent increase in the cross-sectional area of the callus and bone at the fracture line. Consequently, local treatment of fractures with TGF-beta increases the callus formation and strength. The energy absorption and deflection capacities of the healing fractures are preserved.
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Citations
Cited by
THE ROLE OF GROWTH FACTORS IN THE REPAIR OF BONE: BIOLOGY AND CLINICAL APPLICATIONS
LIEBERMAN, J. R., DALUISKI, A., & EINHORN, T. A. (2002) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200206000-00022 · Cited by 932
Enhancement of fracture-healing.
Einhorn, T. A. (1995) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199506000-00016 · Cited by 772
Carano, R. A. D., & Filvaroff, E. H. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02866-6 · Cited by 746
Transforming Growth Factor-β1 to the Bone
Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710
Blood vessel formation and function in bone
Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 441
Metadata
- Authors
- Nielsen, H. M., Andreassen, T. T., Ledet, T., & Oxlund, H.
- Venue
- Acta Orthopaedica Scandinavica
- Published
- 1994-01
- Volume
- 65
- Issue
- 1
- Pages
- 37-41
- ISSN
- 0001-6470 (ISSN-L)
- OpenAlex
- W2089797394
- Cited by
- 158
- References
- 0
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Local injection of TGF-β increases the strength of tibial fractures in the rat. https://app.cochat.ai/papers/10.3109/17453679408993715
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- Nielsen, H. M., Andreassen, T. T., Ledet, T., & Oxlund, H. (1994). Local injection of TGF-β increases the strength of tibial fractures in the rat. Acta Orthopaedica Scandinavica. https://doi.org/10.3109/17453679408993715
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
