Apolipoprotein E genotypes of fertile and infertile men
Open accessAbstract
Lipid components of spermatozoa have an important role in the functional activity of this cell. The protein, apolipoprotein E (apoE), has a central role in lipid transport. The aim of this study was to investigate the distribution of APOE genotypes, ϵ3ϵ3, ϵ3ϵ4, and ϵ2ϵ3, and the corresponding alleles in fertile and infertile males, and to assess the semen parameters from the patients carrying the different alleles. In addition, the levels of cholesterol, phospholipid, and triacylglycerol in spermatozoa, isolated by PureSperm gradient and from seminal plasma in samples from infertile males was compared with respect to the APOE genotype. APOE genotypes were determined by PCR-RFLP on DNA extracted from peripheral blood leucocytes in 108 fertile and 107 infertile men. There was a significant difference between the distribution of APOE genotypes in fertile as compared to infertile males (χ(2) = 9.1, df = 2, p = 0.011). The presence of genotype ϵ3ϵ4 conferred a 3.82 risk factor for male infertility {Odds ratio = 3.82 (1.46-10, p = 0.006)}. Our findings showed that the distribution of APOE genotypes and alleles differed between fertile and infertile individuals and may be a risk factor for male infertility. We suggest that the effects of APOE genotypes may be linked to differences in the efficacy of the expressed apoE isoforms in promoting sperm maturation during epididymal transit.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Male infertility is associated with variations in APOE genotypes.
“Beyond LPG, recently the increased studies have showed that male infertility is associated with variations in APOE genotypes.4,5”
From The First Case of Lipoprotein Glomerulopathy in a Patient With Male Infertility (2026) · cites this paper as [4]
The presence of the ε3ε4 genotype is associated with a 3.82-fold increased risk of male infertility.
“Specifically, the presence of the ε3ε4 genotype was associated with a 3.82-fold increased risk of male infertility.4”
From The First Case of Lipoprotein Glomerulopathy in a Patient With Male Infertility (2026) · cites this paper as [4]
There is a significant difference in the distribution of APOE genotypes between fertile and infertile males.
“A previous experiment explored the correlation between APOE genotype (ε3ε3, ε3ε4 and ε2ε3) and male infertility, which found that there was a significant difference in the distribution of APOE genotypes between fertile and infertile males.”
From The First Case of Lipoprotein Glomerulopathy in a Patient With Male Infertility (2026) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Apolipoprotein E structure: insights into function
Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.06.008 · Cited by 583 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Sonnenwirth, A.C. and Jarett, L. (1980) Gradwohls clinical laboratory methods and diagnosis, Mosby Company, London, UK p. 280.
- World Health Organization (1999) WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Inter- action, 4th ed, Cambridge University Press, Cambridge, UK.
Cited by
Sorted by citations
The First Case of Lipoprotein Glomerulopathy in a Patient With Male Infertility
Ye, C., Wang, Y., Liang, C., Wang, Y., Zhang, C., & Jiang, H. (2026) · Kidney Medicine · doi:10.1016/j.xkme.2026.101308
- Authors
- Setarehbadi, R., Vatannejad, A., Vaisi-Raygani, A., Amiri, I., Esfahani, M., Fattahi, A., & Tavilani, H.
- Affiliations
- Hamedan University of Medical Sciences (IR)
- Corresponding author
- Tavilani, Heidar
- Venue
- Systems Biology in Reproductive Medicine
- Publisher
- Informa UK Limited
- Published
- 2012-05-08
- Volume
- 58
- Issue
- 5
- Pages
- 263-267
- ISSN
- 1939-6368 (ISSN-L)
- 1939-6376
- OpenAlex
- W2132276395
- Cited by
- 17
- References
- 1
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 4 · 2020: 1 · 2017: 2 · 2015: 1 · 2014: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Systems Biology in Reproductive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pennsylvania
- Hamadan University of Medical Sciences
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
- Keywords
- apolipoprotein E, APOE genotype, male infertility, sperm lipid composition, sperm maturation, APOE ε4, genetic risk factors
- MeSH terms
- Analysis of Variance, Cholesterol, Fertility, Gene Frequency, Humans, Infertility, Male, Iran, Male, Phenotype, Phospholipids, Polymorphism, Genetic, Risk Factors, Sperm Count, Sperm Motility, Spermatozoa, Triglycerides, Chi-Square Distribution, Odds Ratio, Polymerase Chain Reaction, Risk Assessment, Genetic Predisposition to Disease, Apolipoprotein E3, Apolipoprotein E2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
