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Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus
Abstract
Precipitating antibodies which reacted with soluble extracts of different human tissues or nuclei including nuclei from calf thymus were found in sera of patients with systemic lupus erythematosus. The antigen was different from DNA and histone, but was associated with protein fractions and insensitive to deoxyribonuclease, ribonuclease and trypsin, but sensitive to periodate treatment. The reactivity was detected by Ouchterlony double-immunodiffusion and by immunoelectrophoresis techniques. The reactive serum factor was shown to migrate in the gamma globulin fraction. The antigen was provisionally termed ‘Sm’ and the reactivity was described to be found in approximately 75% of SLE patients but only very few patients with other disorders.
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Cited by
IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS OF SYSTEMIC LUPUS ERYTHEMATOSUS
Koffler, D., Schur, P. H., & Kunkel, H. G. (1967) · The Journal of Experimental Medicine · doi:10.1084/jem.126.4.607 · Cited by 879
Immunologic Factors and Clinical Activity in Systemic Lupus Erythematosus
Schur, P. H., & Sandson, J. (1968) · New England Journal of Medicine · doi:10.1056/nejm196803072781004 · Cited by 587
Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis
Kurata, N., & Tan, E. M. (1976) · Arthritis & Rheumatism · doi:10.1002/art.1780190309 · Cited by 373
Cell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases
Duvvuri, B., & Lood, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00502 · Cited by 282
Orton, S. M., Peace-Brewer, A., Schmitz, J. L., Freeman, K., Miller, W. C., & Folds, J. D. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.2.297-301.2004 · Cited by 35
Metadata
- Venue
- Classic Papers in Rheumatology
- Publisher
- CRC Press
- Published
- 2001-12-06
- Volume
- 96
- Issue
- 3
- Pages
- 50-51
- OpenAlex
- W1496775456
- Cited by
- 550
- References
- 0
- FWCI
- 20.95
- Type
- book chapter
- Language
- en
- Open access
- closed
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