Modafinil: mechanisms of action
Abstract
Over just a few years, modafinil has become the most popular medication for treating the daytime sleepiness of narcolepsy. Its’ safety and efficacy are well established, but its’ mechanism of action remains poorly understood. This chapter summarizes the neuropharmacology of modafinil, and outlines how research on this clinically important drug has shed light on the basic neurobiology of sleep and wakefulness.
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Modafinil activates central, wake-promoting dopaminergic and noradrenergic mechanisms.
“Modafanil activates central, wake-promoting dopaminergic and noradrenergic mechanisms (25,26)”
From Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men (2010) · cites this paper as [25]
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Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men
Buxton, O. M., Pavlova, M., Reid, E. W., Wang, W., Simonson, D. C., & Adler, G. K. (2010) · Diabetes · doi:10.2337/db09-0699 · Cited by 604 · see citing works
- Authors
- Scammell, T. E.
- Corresponding author
- Thomas E. Scammell
- ORCID
- Thomas E. Scammell
- Venue
- Narcolepsy and Hypersomnia
- Publisher
- CRC Press
- Published
- 2006-12-21
- Pages
- 585-598
- OpenAlex
- W4254759505
- Cited by
- 1
- References
- 0
- FWCI
- 0.00
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- CRC Press eBooks (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- modafinil, mechanism of action, neuropharmacology, narcolepsy, daytime sleepiness, wakefulness-promoting drugs, sleep-wake regulation, adenosine receptor agonists
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