Sleep-deprived cognitive impairment in aging mice is alleviated by rapamycin
Open accessAbstract
BACKGROUND: Sleep deprivation-induced cognitive impairment is a major health concern and an age-related risk factor for dementia. There is an urgent need to develop ways of preventing the adverse neurological effects of sleep deprivation, but current preclinical animal models of short-term sleep deprivation are not well described. METHODS: C57BL6 mice of varying ages were sleep deprived for 4 hours a day for 4 days, and then tested with a Box maze navigation task. RESULTS: Sleep deprived mice at young, middle and older ages showed learning impairment that varied by strain and gender. In general, females were more sensitive to sleep deprivation than males. To determine whether sleep deprivation-induced learning impairment would respond to therapeutic intervention, an independent cohort of mice was treated with rapamycin daily during the 4 days of sleep deprivation. Mice that were sleep deprived and treated with rapamycin showed significant improvement in learning time suggesting that the cognitive impairment might be associated in part with molecular and cellular mechanisms targeted by rapamycin. CONCLUSIONS: The observations from this study suggest that aging mice would be productive models to study pathobiology and therapeutic intervention of cognitive impairment triggered by age-related sleeping disorders in people.
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NF-κB p65 and p38 MAPK signaling pathways are key regulators of inflammation and pro-inflammatory responses.
“Both signaling pathways are key regulators of inflammation and pro-inflammatory responses, which are considered targets for developing anti-inflammatory therapeutic agents [23–26].”
From The potential of GHK as an anti-aging peptide (2020) · cites this paper as [26]
The Introduction and Results and Discussion discuss mTOR, nitric oxide signaling, and vascular inflammation, but do not identify NF-κB p65 or p38 MAPK as regulators of inflammatory responses or targets for anti-inflammatory agents. Searches for both pathways and anti-inflammatory therapeutic agents found no passage addressing the attributed claim. Page numbers were unavailable in our copy. (LLM, conf=0.74)
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References 19 · Cited by 10
- Authors
- Mukherjee, K., Lee, A. J., Zhu, L., Darvas, M., & Ladiges, W.
- Affiliations
- University of Washington (US)
- Corresponding author
- Warren Ladiges
- Venue
- Aging Pathobiology and Therapeutics
- Publisher
- Ant Publishing
- Published
- 2019-12-27
- Volume
- 1
- Issue
- 1
- Pages
- 05-09
- ISSN
- 2690-1803 (ISSN-L)
- PMC
- PMC8789090
- OpenAlex
- W2998283591
- Semantic Scholar
- e4b69b89394dd06f9786f0446b2fdd4b6d43328f
- Cited by
- 10
- References
- 19
- Citations by year
- 2024: 2 · 2023: 2 · 2021: 1 · 2020: 5
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Aging Pathobiology and Therapeutics (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG067193, AG057381, R01AG057381)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, cognitive impairment, aging, rapamycin, learning disabilities, mazes, sex differences, dementia, mTOR signaling
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