Clinical Effects of Brown Seaweed, Undaria pinnatifida (wakame), on Blood Pressure in Hypertensive Subjects.
Open accessAbstract
This was conducted to examine the effects of brown seaweed (wakame) on blood pressure and serum biochemical parameters in hypertensive subjects. Of the 37 elderly out-patients with hypertension who started the study, 36 of them completed it. This study was a randomly assigned, case-controlled one. Nineteen patients received a daily dose of 5g of dried wakame powder packed in 12 capsules. Eighteen gender-matched subjects with age difference±2 years, and starting time of participation within±2 weeks, were selected as the control group. Patients visited the clinic every 4 weeks. The observation period was 8 weeks. In the wakame group, the average amount of wakame ingested was 3.3g. The systolic blood pressure (SBP) in this group dropped 13mmHg below the baseline (p<0.01) after 4 weeks, and 8mmHg (p<0.05) after 8 weeks. The diastolic blood pressure (DBP) decreased by 9mmHg (p<0.01) after 4 weeks and by 8mmHg (p<0.05) after 8 weeks. In the control group, no significant changes were seen in either SBP or DBP. However, the differences in reduction in SBP and DBP were significant between the wakame and control groups. Regarding clinical chemistry data, hypercholesterolemia in the wakame group decreased by 8% after 4 weeks. No other abnormal changes were observed in either group. We conclude that wakame has beneficial effects as a supplemental regimen in the treatment of hypertension.
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Consumption of dried wakame powder significantly lowered systolic and diastolic blood pressure in older hypertensive adults.
“consumption of dried wakame powder significantly lowered systolic and diastolic blood pressure in older hypertensive adults [79]”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [79]
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References 35 · Cited by 66
Research works printed but not linked: 4
- Japan Hypertension Society Working Group (Kaneko, Y. et al., 1994): Guideline for clinical evaluation of drugs in research and development, in Handbook of Guidelines for Development of New Drugs, Yakugyo Jiho, Tokyo, pp. 222-239.
- Mitsuoka, T. (1994): Current status and future prospects of studies on intestinal flora and dietary factors, in Intestinal Flora and Dietary Factors, ed. by Mitsuoka, T., Gakkai Shuppan Center, Tokyo, pp. 1-14.
- Story, J.A., Kritchevsky, D., and Eastwood, M.A. (1979): Dietary fibre-bile acid interactions, in Dietary Fiber-Chemistry and Nutrition, ed. by Inglett, G.E., and Falkenag, S.I., Aca- demic Press, New York, pp. 49-55.
- Harlan, W.R., and Harlan, L.C. (1995): Blood pressure and calcium and magnecium intake, in Hypertension-Pathophysiology, Diagnosis and Management, 2nd ed., ed. by Laragh, J.H., and Briwn, B.M., Raven Press, New York, pp. 1143-1154.
- Authors
- HATA, Y., NAKAJIMA, K., UCHIDA, J.-I., HIDAKA, H., & NAKANO, T.
- Affiliations
- Kyorin University (JP)
- Tokiwa University (JP)
- Riken Vitamin Co., Ltd. (Japan) (JP)
- ORCID
- NAKANO, Takahisa
- Venue
- Journal of Clinical Biochemistry and Nutrition
- Published
- 2001
- Volume
- 30
- Pages
- 43-53
- ISSN
- 0912-0009 (ISSN-L)
- 1880-5086
- OpenAlex
- W2070237122
- Cited by
- 66
- References
- 35
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 3 · 2023: 12 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 4 · 2013: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Biochemistry and Nutrition (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- Undaria pinnatifida, brown algae, hypertension, blood pressure reduction, systolic blood pressure, diastolic blood pressure, hypercholesterolemia, serum cholesterol, dietary supplementation, elderly patients
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