Cited by 121Photodynamic Therapy Research StudiesGlioma Diagnosis and TreatmentNanoplatforms for cancer theranostics

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Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising dual strategy for local tumor control

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Schipmann, Stephanie, Müther, Michael, Stögbauer, Louise, Zimmer, Sebastian, Brokinkel, Benjamin, Holling, Markus, Grauer, Oliver, Suero Molina, Eric, Warneke, Nils, Stummer, Walter·2021·Journal of Neurosurgery

DOI 10.3171/2019.11.jns192443

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Abstract

OBJECTIVE: High-grade glioma (HGG) prognosis remains dismal, with inevitable, mostly local recurrence. Regimens for improving local tumor control are therefore needed. Photodynamic therapy (PDT) using porfimer sodium has been investigated but was abandoned due to side effects and lack of survival benefits. Intracellular porphyrins induced by 5-aminolevulinic acid (5-ALA) are approved for fluorescence-guided resections (FGRs), but are also photosensitizers. Activated by light, they generate reactive oxygen species with resultant cytotoxicity. The authors present a combined approach of 5-ALA FGR and PDT. METHODS: After 5-ALA FGR in recurrent HGG, laser diffusors were strategically positioned inside the resection cavity. PDT was applied for 60 minutes (635 nm, 200 mW/cm diffusor, for 1 hour) under continuous irrigation for maintaining optical clarity and ventilation with 100% oxygen. MRI was performed at 24 hours, 14 days, and every 3 months after surgery, including diffusion tensor imaging and apparent diffusion coefficient maps. RESULTS: Twenty patients were treated. One surgical site infection after treatment was noted at 6 months as the only adverse event. MRI revealed cytotoxic edema along resection margins in 16 (80%) of 20 cases, mostly annular around the cavity, corresponding to prior laser diffusor locations (mean volume 3.3 cm 3 ). Edema appeared selective for infiltrated tissue or nonresected enhancing tumor. At the 14-day follow-up, enhancement developed in former regions of edema, in some cases vanishing after 4–5 months. Median progression-free survival (PFS) was 6 months (95% CI 4.8–7.2 months). CONCLUSIONS: Combined 5-ALA FGR and PDT provides an innovative and safe method of local tumor control resulting in promising PFS. Further prospective studies are warranted to evaluate long-term therapeutic effects.

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Wong, E. T., Hess, K. R., Gleason, M. J., Jaeckle, K. A., Kyritsis, A. P., Prados, M. D., Levin, V. A., & Yung, W. K. A. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.8.2572 · Cited by 902
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Show all 42 references

Research works printed but not linked: 1

Muller PJ, Wilson BC: A randomized two arm clinical trial of photophrin PDT and standard therapy in high grade gliomas—phase III trial, in Proceedings of the 6th International Symposium on Photodynamic Diagnosis and Therapy in Clinical Practice. Brixen/Bressanone, Italy, October 10–14, 2006

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Authors: Schipmann, S., Müther, M., Stögbauer, L., Zimmer, S., Brokinkel, B., Holling, M., Grauer, O., Suero Molina, E., Warneke, N., & Stummer, W.
Affiliations: Department of Neurosurgery,
Research Institute of Radiology (BY)
University Hospital Münster (DE)
Corresponding author: Schipmann, Stephanie
ORCID: Schipmann, Stephanie
Müther, Michael
Zimmer, Sebastian
Brokinkel, Benjamin
Holling, Markus
Grauer, Oliver
Stummer, Walter
Venue: Journal of Neurosurgery
Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
Published: 2021-02
Volume: 134
Issue: 2
Pages: 426-436
ISSN: 0022-3085 (ISSN-L)
1933-0693
DOI: 10.3171/2019.11.jns192443
OpenAlex: W3001797168
Cited by: 121
References: 42
Citations by year: 2026: 10 · 2025: 18 · 2024: 29 · 2023: 20 · 2022: 22 · 2021: 15
FWCI: 9.03
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of neurosurgery (publishedVersion)
PubMed (publishedVersion)
Funders: Westfälische Wilhelms-Universität Münster
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: recurrent glioblastoma, 5-aminolevulinic acid, fluorescence-guided resection, photodynamic therapy, porphyrins, local tumor control, cytotoxic edema, progression-free survival, high-grade glioma

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Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising dual strategy for local tumor control

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