The DOI matches its Crossref record.
Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury
Abstract
✓ High-dose methylprednisolone (15 to 30 mg/kg), administered 45 minutes after severe contusion injury (400 gm-cm) to cat spinal cords, rapidly reverses the typical posttraumatic ischemia that occurs in spinal injuries. White matter blood flow improves despite the systemic hypotension associated with bolus intravenous injections of such massive corticosteroid doses. In addition, this treatment facilitates extracellular calcium ionic recovery in contused spinal cords, and salvages evoked potential activity that is lost in untreated cats. These data suggest that high-dose corticosteroid treatment causes local vasodilation of spinal cord blood vessels. The consequent blood flow increase may account for the beneficial effects of high-dose corticosteroid treatment on both functional recovery and histopathological appearance of injured spinal cords.
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Citations
Cited by
Tator, C. H., & Fehlings, M. G. (1991) · Journal of Neurosurgery · doi:10.3171/jns.1991.75.1.0015 · Cited by 1,577
Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion
Sapolsky, R. M. (1996) · Stress · doi:10.3109/10253899609001092 · Cited by 738
Central nervous system trauma and stroke
Hall, E. D., & Braughler, J. M. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90057-9 · Cited by 586
Chapter 4 Cell death in models of spinal cord injury
Beattie, M. S., Hermann, G. E., Rogers, R. C., & Bresnahan, J. C. (2002) · Progress in Brain Research · doi:10.1016/s0079-6123(02)37006-7 · Cited by 453
Citron, B. A., Arnold, P. M., Sebastian, C., Qin, F., Malladi, S., Ameenuddin, S., Landis, M. E., & Festoff, B. W. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7523 · Cited by 126
Metadata
- Authors
- Young, W., & Flamm, E. S.
- Venue
- Journal of Neurosurgery
- Published
- 1982-11
- Volume
- 57
- Issue
- 5
- Pages
- 667-673
- ISSN
- 0022-3085 (ISSN-L)
- OpenAlex
- W2021789707
- Cited by
- 320
- References
- 0
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury. https://app.cochat.ai/papers/10.3171/jns.1982.57.5.0667
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- Young, W., & Flamm, E. S. (1982). Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury. Journal of Neurosurgery. https://doi.org/10.3171/jns.1982.57.5.0667
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
