Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 128

The DOI matches its Crossref record.

Pituitary adenomas in childhood and adolescence: Results of transsphenoidal surgery

Partington, Michael D., Davis, Dudley H., Laws, Edward R., Scheithauer, Bernd W.·1994·Journal of Neurosurgery
DOI 10.3171/jns.1994.80.2.0209
Open this paper in CoChat — free account

Abstract

✓ Pituitary adenomas are uncommon in childhood. Between 1975 and 1988, 36 patients underwent trans-sphenoidal resection at the Mayo Clinic before their 17th birthday. Fifteen (41.7%) had prolactin (PRL)-secreting tumors, 16 (44.4%) had adrenocorticotropic hormone (ACTH)-secreting tumors (including two patients with Nelson-Salassa syndrome), and three (8.3%) had tumors secreting growth hormone (GH); two patients (5.6%) had clinically nonfunctioning tumors. Of the 36 patients, 21 (58.3%) were girls, and girls predominated in every group except that with ACTH-secreting tumors, where they accounted for only 37.5% of the patients. The average age at the time of surgery was 14.7 ± 2.2 years, the youngest patient being 7.3 years old. The ACTH-secreting tumors were associated with an earlier onset of symptoms than the other tumor types: six (37.5%) of 16 patients became symptomatic before 10 years of age, compared with two (10.0%) of the 20 other patients. Presenting symptoms primarily reflected endocrine dysfunction, with neurological presentation (visual field deficits) occurring in only two patients. There were no deaths in this patient group. Significant operative morbidity included steroid-induced psychosis in one patient and diabetes insipidus in three, which resolved in two. Plurihormonal tumors, broadly defined as tumors producing more than one hormone, were common, comprising five (36%) of 14 PRL-secreting tumors, all three GH-secreting tumors, and one of two clinically nonfunctioning tumors, or 25.7% overall. Macroadenomas accounted for 89% of plurihormonal tumors. Long-term follow-up review (median > 5 years) revealed good control of PRL-secreting tumors (although five of 15 patients had received postoperative radiotherapy), contrasted with a 25% late recurrence rate for ACTH-secreting tumors, which had an 80% initial remission rate. The majority of patients had good endocrine function, including reproductive function. It is concluded that: 1) although pediatric pituitary adenomas occur primarily in adolescence, Cushing's disease is found at any age; 2) transsphenoidal surgery is feasible and safe in this age group; 3) plurihormonal tumors occur more frequently in the pediatric age group than in adults; and 4) long-term control rates in PRL- and ACTH-secreting tumors are probably similar to those seen in adults.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3171/jns.1994.80.2.0209

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 51

  1. Beck W, 1979, Eur J Pediatr, 130, 193, 10.1007/BF00455266 · DOI
  2. Blumberg DL, 1989, Pediatrics, 83, 998, 10.1542/peds.83.6.998 · doi:10.1542/peds.83.6.998
  3. Buchfelder M, 1985, Acta Neurochir Suppl, 35, 101, 10.1007/978-3-7091-8813-2_17 · doi:10.1007/978-3-7091-8813-2_17
  4. 10.3171/jns.1987.66.2.0204 · DOI
  5. Cheyne KL, 1988, J Adolesc Health, 9, 331, 10.1016/0197-0070(88)90260-4 · doi:10.1016/0197-0070(88)90260-4
  6. Dalzell GW, 1987, Clin Endocrinol, 26, 169, 10.1111/j.1365-2265.1987.tb00773.x · DOI
  7. Di Rocco C, 1982, Childs Brain, 9, 165
  8. Faggiano M, 1983, Acta Endocrinol, 102, 167, 10.1530/acta.0.1020167 · doi:10.1530/acta.0.1020167
  9. 10.3171/jns.1983.59.4.0590 · doi:10.3171/jns.1983.59.4.0590
  10. Gaini SM, 1977, Mod Probl Paediatr, 18, 220
  11. Gold EB, 1981, Epidemiol Rev, 3, 163, 10.1093/oxfordjournals.epirev.a036232 · DOI
  12. Grigsby PW, 1988, Am J Clin Oncol, 11, 607, 10.1097/00000421-198812000-00001 · doi:10.1097/00000421-198812000-00001
  13. Haddad SF, 1991, Neurosurgery, 29, 509, 10.1227/00006123-199110000-00004 · doi:10.1227/00006123-199110000-00004
  14. Hoffman HJ, 1982, Pediatric Neurosurgery: Surgery of the Developing Nervous System., 493
  15. 10.1016/S0022-3476(78)81170-6 · doi:10.1016/s0022-3476(78)81170-6
  16. 10.1002/1097-0142(19810215)47:4<761::AID-CNCR2820470422>3.0.CO;2-L · doi:10.1002/1097-0142(19810215)47:4<761::aid-cncr2820470422>3.0.co;2-l
  17. 10.3171/jns.1987.67.6.0816 · DOI
  18. Kane LA, 1992, Endocrine Pathol, 3, S17
  19. Kanter SL, 1985, Pediatr Neurosci, 12, 202, 10.1159/000120251 · doi:10.1159/000120251
  20. Kim MS, 1986, Pediatr Pathol, 6, 151, 10.3109/15513818609037707 · doi:10.3109/15513818609037707
  21. Laws ER, 1988, Operative Neurosurgical Techniques: Indications, Methods and Results, 309
  22. 10.3171/jns.1983.58.5.0685 · doi:10.3171/jns.1983.58.5.0685
  23. Laws ER, 1987, Prog Exp Tumor Res, 30, 359, 10.1159/000413694 · doi:10.1159/000413694
  24. Levy SR, 1982, Am J Dis Child, 136, 605
  25. Ludecke DK, 1987, Prog Exp Tumor Res, 30, 362, 10.1159/000413695 · doi:10.1159/000413695
  26. Maira G, 1980, J Microsurg, 1, 276, 10.1002/micr.1920010406 · doi:10.1002/micr.1920010406
  27. Mampalam TJ, 1988, Ann Intern Med, 109, 487, 10.7326/0003-4819-109-6-487 · DOI · Paper page
  28. 10.1056/NEJM199004053221405 · DOI · Paper page
  29. Mickle JP, 1989, Concepts in Pediatric Neurosurgery., 9, 65
  30. Miller WL, 1979, J Clin Endocrinol Metab, 48, 1017, 10.1210/jcem-48-6-1017 · doi:10.1210/jcem-48-6-1017
  31. Moss-Salentijn L, 1985, Surgery of the Paranasal Sinuses., 1
  32. 10.1097/00006123-198708000-00015 · DOI
  33. Newman CB, 1981, Am J Dis Child, 135, 259, 10.1001/archpedi.1981.02130270051017 · doi:10.1001/archpedi.1981.02130270051017
  34. 10.3171/jns.1975.43.4.0437 · doi:10.3171/jns.1975.43.4.0437
  35. Pullins DI, 1984, Histopathology, 8, 157, 10.1111/j.1365-2559.1984.tb02330.x · doi:10.1111/j.1365-2559.1984.tb02330.x
  36. Raiti S, 1982, Childs Brain, 9, 147
  37. 10.3171/jns.1978.49.2.0163 · doi:10.3171/jns.1978.49.2.0163
  38. Sack J, 1984, Acta Paediatr Scand, 73, 863, 10.1111/j.1651-2227.1984.tb17792.x · doi:10.1111/j.1651-2227.1984.tb17792.x
  39. Scamoni C, 1991, J Neurosurg Sci, 35, 9
  40. Scheithauer BW, 1986, Semin Diagn Pathol, 3, 69
  41. Schroffner WG, 1976, Arch Intern Med, 136, 1164, 10.1001/archinte.1976.03630100076020 · DOI
  42. Shalet SM, 1986, Acta Endocrinol Suppl, 279, 434, 10.1530/acta.0.112S434 · doi:10.1530/acta.0.112s434
  43. Slonim AE, 1982, J Pediatr, 101, 236, 10.1016/S0022-3476(82)80131-5 · doi:10.1016/s0022-3476(82)80131-5
  44. Spence HJ, 1972, Am J Dis Child, 123, 504, 10.1001/archpedi.1972.02110110132018 · doi:10.1001/archpedi.1972.02110110132018
  45. Stegner H, 1985, Eur J Pediatr, 143, 221, 10.1007/BF00442145 · doi:10.1007/bf00442145
  46. 10.1056/NEJM198404053101405 · DOI
  47. Sumner TE, 1982, Pediatr Radiol, 12, 81, 10.1007/BF00972437 · doi:10.1007/bf00972437
  48. Tindall GT, 1986, Disorders of the Pituitary.
  49. 10.3171/jns.1990.72.3.0363 · DOI
  50. 10.1016/S0022-3476(77)81242-0 · doi:10.1016/s0022-3476(77)81242-0
  51. Zampieri P, 1983, Surg Neurol, 20, 498, 10.1016/0090-3019(83)90034-4 · doi:10.1016/0090-3019(83)90034-4

Cited by

See all 128

Metadata

Authors
Partington, M. D., Davis, D. H., Laws, E. R., & Scheithauer, B. W.
Venue
Journal of Neurosurgery
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Published
1994-02
Volume
80
Issue
2
Pages
209-216
ISSN
0022-3085
DOI
10.3171/jns.1994.80.2.0209
Cited by
128
References
0

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Pituitary adenomas in childhood and adolescence: Results of transsphenoidal surgery. https://app.cochat.ai/papers/10.3171/jns.1994.80.2.0209
The paper
Partington, M. D., Davis, D. H., Laws, E. R., & Scheithauer, B. W. (1994). Pituitary adenomas in childhood and adolescence: Results of transsphenoidal surgery. Journal of Neurosurgery. https://doi.org/10.3171/jns.1994.80.2.0209

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.