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Cited by 44Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCognitive Abilities and Testing

Relationship between APOE Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort

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Habes, M., Toledo, J.B., Resnick, S.M., Doshi, J., Van der Auwera, S., Erus, G., Janowitz, D., Hegenscheid, K. +5 more·2016·American Journal of Neuroradiology
DOI 10.3174/ajnr.a4805PMC PMC5154957
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Abstract

BACKGROUND AND PURPOSE: The presence of the apolipoprotein E ε4 allele is the strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that apolipoprotein E ε4 carriers and noncarriers may already differ in imaging patterns in midlife. We therefore sought to identify the effect of apolipoprotein E genotype on brain atrophy across almost the entire adult age span by using advanced MR imaging-based pattern analysis. MATERIALS AND METHODS: We analyzed MR imaging scans of 1472 participants from the Study of Health in Pomerania (22-90 years of age). We studied the association among age, apolipoprotein E ε4 carrier status, and brain atrophy, which was quantified by using 2 MR imaging-based indices: Spatial Pattern of Atrophy for Recognition of Brain Aging (summarizing age-related brain atrophy) and Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease (summarizing Alzheimer disease-like brain atrophy patterns), as well as the gray matter volumes in several Alzheimer disease- and apolipoprotein E-related ROIs (lateral frontal, lateral temporal, medial frontal, and hippocampus). RESULTS: No significant association was found between apolipoprotein E ε4 carrier status and the studied ROIs or the MR imaging-based indices in linear regression models adjusted for age, sex, and education, including an interaction term between apolipoprotein E and age. CONCLUSIONS: Our study indicates that measurable apolipoprotein E-related brain atrophy does not occur in early adulthood and midlife and suggests that such atrophy may only occur more proximal to the onset of clinical symptoms of dementia.

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Authors
Habes, M., Toledo, J. B., Resnick, S. M., Doshi, J., Van der Auwera, S., Erus, G., Janowitz, D., Hegenscheid, K., Homuth, G., Völzke, H., Hoffmann, W., Grabe, H. J., & Davatzikos, C.
Affiliations
  • University of Pennsylvania (US)
  • National Institutes of Health (US)
  • Universität Greifswald (DE)
  • German Center for Neurodegenerative Diseases (DE)
ORCID
Venue
American Journal of Neuroradiology
Publisher
American Society of Neuroradiology (ASNR)
Published
2016-05-12
Volume
37
Issue
9
Pages
1636-1642
ISSN
  • 0195-6108 (ISSN-L)
  • 1936-959X
DOI
10.3174/ajnr.a4805
PMC
PMC5154957
OpenAlex
W2364709612
Cited by
44
References
41
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 3 · 2017: 3
FWCI
4.44
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • American Journal of Neuroradiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DZNE Pub (submittedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (01ZZ0403, 01ZZ9603, 03ZIK012, 01ZZ0103)
  • Bundesministerium für Bildung und Forschung (01ZZ9603, 01ZZ0103, and 01ZZ0403, 03ZIK012, 01ZZ0403, and 01ZZ0403, 01ZZ0103, 01ZZ9603)
  • Alfried Krupp von Bohlen und Halbach-Stiftung
  • Universität Greifswald
  • Ministry of Cultural Affairs
  • National Institutes of Health (AG010124, AG032953, NS053488, AG017586)
  • National Institute on Aging (P30AG010124, P01AG017586, Z01AG000191, R01AG014971, P01AG032953)
  • National Institute of Neurological Disorders and Stroke (P50NS053488)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
APOE ε4, APOE genotype, brain atrophy, Alzheimer's disease, gray matter volume, hippocampus, Study of Health in Pomerania, dementia risk
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Female, Genotype, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Apolipoprotein E4, Young Adult

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