β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats
Open accessAbstract
The turnover of the oxidized form of nicotinamide adenine dinucleotide (NAD 1 ) has attracted interest in regard to longevity.Thus, compounds that can rapidly increase the cellular NAD 1 concentration have been surveyed by many researchers.Of those, b-nicotinamide mononucleotide (b-NMN) has been focused on.Studies on the biosynthesis of NAD 1 from b-NMN have been reported at the cellular level, but not at the whole animal level.In the present study, we investigated whether b-NMN is superior to nicotinamide (Nam) as a precursor of NAD 1 in whole animal experiments.To this end we compared the NAD 1 concentration in the blood and the urinary excretion amounts of NAD 1 catabolites.Rats were intraperitoneally injected with b-NMN or Nam.After the injection, blood samples and urine samples were collected at 3-h intervals.The concentration of blood total NAD (NAD 1 1NADH) in each sample showed no significant differences between the two groups.The urinary excretion amounts of NAD 1 catabolites in the urine samples collected at 3-6 h after the injection were lower in the b-NMN group than in the Nam group.These results suggest that b-NMN is retained in the body for longer than Nam.
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It remains unclear why NR administration raises NAD+ levels more than NAM and NA treatment, while NMN and NAM administration show no difference in blood and liver NAD levels.
“It is still unclear why NR administration increases NAD+ levels more than NAM and NA treatment [63], while NMN and NAM administration showed no difference in NAD levels in blood and liver [90].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [90]
Experimental — accuracy not yet measuredBlood and urine pharmacokinetic data in rats suggest that intraperitoneally administered NMN is retained in the body longer than NAM.
“Furthermore, blood and urine pharmacokinetic data performed in rats suggested that NMN administered intraperitoneally appears to be retained in the body longer than NAM [90].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [90]
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References 18 · Cited by 23
- Authors
- KAWAMURA, T., MORI, N., & SHIBATA, K.
- Affiliations
- University of Shiga Prefecture (JP)
- Corresponding author
- SHIBATA, Katsumi
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 2016
- Volume
- 62
- Issue
- 4
- Pages
- 272-276
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W2526023525
- Cited by
- 23
- References
- 18
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Nutritional Science and Vitaminology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Keywords
- nicotinamide mononucleotide, nicotinamide, NAD biosynthesis, tissue retention, anti-aging, longevity, rats
- MeSH terms
- Aging, Animals, Injections, Intraperitoneal, Longevity, Male, NAD, Niacinamide, Nicotinamide Mononucleotide, Rats, Wistar, Rats
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