Effect of Turkesterone on the Pancreas Histology and Function in Diabetic Rats
Open accessAbstract
Introduction: The wide-ranging positive effects of phytoecdisteroids suggest use them as drugs for the treatment of diabetes and related diseases.Among phytoecdysteroids, a well-expressed hypoglycemic effect is known for turke sterone.Objective: We aimed to determine the effect of turke sterone on the endocrine and exocrine parameters of the pancreas in alloxan-induced diabetic rats.Material and Methods: White outbred rats were divided into 4 groups to receive saline or a single dose of alloxan (170 mg/kg, intraperitoneal) and/or turkesterone (10 mg/kg/24 h) and glibenclamide (5 mg/kg/24 h) for 10 days.For histological analysis the tail portion of the pancreas was kept in formalin for 3 days, dried in ethanol, parafinized and then stained with hematoxylin-eosin.The glucose, insulin, C-peptide and total protein level in serum, as well as α-amylase activity in serum and pancreas homogenate, were identified by using special kits (Human.Germany).Results: Diabetes caused complete destruction of the islet apparatus and partial destruction of the pancreatic acini tissue.Treatment with turkesterone of alloxan-induced diabetic rats resulted in restoration of the histostructure of endo-and exocrine pancreas, increase of serum glucose as well as decrease insulin, C-peptide, and total protein level.In addition, turkesterone treatment of alloxan-induced diabetic rats led to an approximation of α-amylase activity of pancreas and serum to control value. Conclusion:This study has shown that turkesterone led to improving the exocrine and endocrine function in alloxan-indused diabetic rats.Hence, it can be recommended for further testing as an anti-pancreatic and anti-diabetic drug in humans.
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Turkesterone exhibited beneficial effects on endocrine and exocrine function in alloxan-induced diabetic rats, suggesting potential therapeutic application in diabetes management.
“Additionally, turkesterone exhibited beneficial effects on the endocrine and exocrine function in alloxan-induced diabetic rats, suggesting its potential therapeutic application in diabetes management [225].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [225]
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References 15 · Cited by 5
Research works printed but not linked: 5
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- Mamatkhanov AU, Yakubova MR, Syrov VN. Isolation of turkesterone from the epigeal part of Ajugaturkestanica and its anabolic activity. Chem Nat Compounds 1998; 34(2): 150-154.
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- Authors
- LS, K., SO, R., & VN, S.
- Affiliations
- National University of Uzbekistan (UZ)
- Corresponding author
- LS, Kuchkarova
- Venue
- International Journal of Current Research and Review
- Publisher
- Radiance Research Academy
- Published
- 2020
- Volume
- 12
- Issue
- 21
- Pages
- 02-05
- ISSN
- 0975-5241 (ISSN-L)
- 2231-2196
- OpenAlex
- W3105003510
- Cited by
- 5
- References
- 15
- Citations by year
- 2026: 2 · 2024: 2 · 2021: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- International Journal of Current Research and Review (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- turkesterone, phytoecdysteroids, alloxan-induced diabetes, pancreatic histology, pancreatic islets, pancreatic acini, pancreatic exocrine function, pancreatic endocrine function, insulin, C-peptide, serum glucose, alpha-amylase, glibenclamide, antidiabetic drugs
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