The DOI matches its Crossref record.
Prolactin Secretion in vitro: Effects of Gonadal and Adrenal Cortical Steroids.
Abstract
Effects of estradiol (E), progesterone (P), testosterone (T), cortisol (F) and corticosterone (B) on prolactin production by rat adenohypophysis in vitro were examined. Addition of P (1 and 2 μg/ml), T (1 and 2 μg/ml), B (1 and 20 μg/ml) or F (0.5 and 5.0 μg/ml to culture medium did not influence prolactin secretion; however, F at 10 μg/ml significantly depressed prolactin production in vitro. This depressant effect of F, however, cannot be regarded as physiological due to the high concentration used. Incorporation of E into medium at concentrations of 0.05 and 0.5 μg/ml significantly increased prolactin secretion whereas E at 2.0 μg/ml was without effect. These observations indicate that only E, of all steroids tested, can act at the pituitary level to influence prolactin secretion. The effects of other steroid hormones on prolactin secretion in vivo are probably mediated via pathways other than by a direct effect on the adenohypophy-sis.
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In the citing paper
“From the experimental data obtained in rats, estrogen appears to cause the enhanced PRL release by exerting a dual action via hypothalamic suppression of the PRLinhibiting factor and direct stimulation of pituitary lactotrophs. (1-3).”
From Augmentation of prolactin secretion by estrogen in hypogonadal women (1974) · cites this paper as [3]
In the citing paper
“This positive feedback relationship was maintained even when a large dose of estradiol benzoate was used (500 μg/day × 6 days) (2, 3).”
From Augmentation of prolactin secretion by estrogen in hypogonadal women (1974) · cites this paper as [3]
In the citing paper
“Evidence that estrogen promotes pituitary prolactin (PRL)¹ secretion is afforded by the finding of an increased pituitary PRL content and serum PRL concentrations following exogenous estrogen treatment in rats (1-3).”
From Augmentation of prolactin secretion by estrogen in hypogonadal women (1974) · cites this paper as [3]
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Cited by
Augmentation of prolactin secretion by estrogen in hypogonadal women
Yen, S. S., Ehara, Y., & Siler, T. M. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107600 · Cited by 222
Metadata
- Authors
- Nicoll, C. S., & Meites, J.
- Affiliations
- Michigan State University (US)
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1964-11-01
- Volume
- 117
- Issue
- 2
- Pages
- 579-583
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2331932869
- Cited by
- 53
- References
- 0
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- prolactin secretion, sex steroids, adrenal cortex hormones, estradiol, progesterone, testosterone, cortisol, corticosterone, anterior pituitary, pituitary hormone regulation, rats
- MeSH terms
- Adrenal Cortex Hormones, Corticosterone, Estradiol, Gonads, Hydrocortisone, Pharmacology, Physiology, Pituitary Gland, Progesterone, Prolactin, Research, Testosterone, Tissue Culture Techniques, In Vitro Techniques
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- CoChat. (2026). Citation check: Prolactin Secretion in vitro: Effects of Gonadal and Adrenal Cortical Steroids. https://app.cochat.ai/papers/10.3181/00379727-117-29643
- The paper
- Nicoll, C. S., & Meites, J. (1964). Prolactin Secretion in vitro: Effects of Gonadal and Adrenal Cortical Steroids. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-117-29643
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
