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Cited by 48Amino Acid Enzymes and MetabolismBarrier Structure and Function StudiesRNA and protein synthesis mechanisms

Uptake of Radiolabeled Essential Amino Acids by Brain Following Arterial Injection

Oldendorf, W. H.·1971·Experimental Biology and Medicine
DOI 10.3181/00379727-136-35270
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Abstract

14C-labeled amino acids were injected into rat common carotid artery mixed with 3H2O, with decapitation 15 sec later. The ratio of 14C to 3H in brain was compared with the same ratio in the injected solution allowing expression of brain uptake of amino acid as a percentage of 3H2O uptake. Eighteen amino acids showed a range of uptake between 2.24 and 54.5%. Those amino acids ordinarily considered nutritionally essential in the rat are taken up to a greater extent than nonessentials. The exception is tyrosine which is not nutritionally essential to the total organism because it is available from hydroxylation of phenylalanine. The large uptake of tyrosine by brain may be related to the absence in brain of phenylalanine hydroxylase thus necessitating an external source.

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Crossref · 10.3181/00379727-136-35270

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  • BCAAs and other large neutral amino acids are transported readily across the blood-brain barrier for transamination or delivery to neurons.

    “BCAAs and other large neutral amino acids are transported quite readily across the BBB for transamination or delivery to neurons (Conway and Hutson, 2016;Oldendorf, 1971).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Oldendorf, 1971

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Authors
Oldendorf, W. H.
Affiliations
United States Department of Veterans Affairs (US)
Corresponding author
Oldendorf, W. H.
Venue
Experimental Biology and Medicine
Publisher
Frontiers Media SA
Published
1971-02-01
Volume
136
Issue
2
Pages
385-386
ISSN
  • 0071-3384 (ISSN-L)
  • 1535-3702
  • 1535-3699
DOI
10.3181/00379727-136-35270
OpenAlex
W2000188123
Cited by
48
References
0
Citations by year
2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1
FWCI
1.14
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
essential amino acids, arterial injection, 14C-labeled amino acids, tyrosine, phenylalanine hydroxylase, phenylalanine, rats
MeSH terms
Amino Acids, Animals, Blood-Brain Barrier, Brain, Carbon Isotopes, Carotid Arteries

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