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Cancer Detection and Therapy. Affinity of Neoplastic, Embryonic, and Traumatized Tissues for Porphyrins and Metalloporphyrins.
Abstract
These experiments show that all porphyrins tested accumulate in neoplastic (induced and transplanted sarcomas, spontaneous and transplanted mammary carcinomas), embryonic and regenerating tissues. Introduction of a metal (zinc) into the porphyrin molecule did not destroy the tendency of the porphyrin to concentrate in tumors. The tendency of injected porphyrins and metalloporphyrins to accumulate in lymph nodes may limit the therapeutic usefulness of these compounds in all neoplastic diseases except lymphatic leukemias. The possibility of using small doses of radioactive metalloporphyrins for detecting deep cancer is being investigated.
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Citations
Cited by
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O’Connor, A. E., Gallagher, W. M., & Byrne, A. T. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00585.x · Cited by 1,191
Photodynamic therapy in dermatology
Kalka, K., Merk, H., & Mukhtar, H. (2000) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(00)90209-3 · Cited by 522
Current Challenges and Opportunities of Photodynamic Therapy against Cancer
Huis in ‘t Veld, R. V., Heuts, J., Ma, S., Cruz, L. J., Ossendorp, F. A., & Jager, M. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020330 · Cited by 159
Metadata
- Authors
- Figge, F. H. J., Weiland, G. S., & Manganiello, L. O. J.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1948-07-01
- Volume
- 68
- Issue
- 3
- Pages
- 640-641
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2318616726
- Cited by
- 371
- References
- 0
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cancer Detection and Therapy. Affinity of Neoplastic, Embryonic, and Traumatized Tissues for Porphyrins and Metalloporphyrins. https://app.cochat.ai/papers/10.3181/00379727-68-16580
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- Figge, F. H. J., Weiland, G. S., & Manganiello, L. O. J. (1948). Cancer Detection and Therapy. Affinity of Neoplastic, Embryonic, and Traumatized Tissues for Porphyrins and Metalloporphyrins. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-68-16580
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.