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Cited by 263Child and Adolescent Psychosocial and Emotional DevelopmentTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 284 of the 284 references it cites were found in a registry or an index.

Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders

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Rao, Uma, Chen, Li-Ann·2009·Dialogues in Clinical Neuroscience
DOI 10.31887/dcns.2009.11.1/uraoPMC PMC2766280
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Abstract

Depressive illness beginning early in life can have serious developmental and functional consequences. Therefore, understanding the disorder during this developmental stage is critical for determining its etiology and course, as well as for developing effective intervention strategies. This paper summarizes current knowledge regarding the etiology, phenomenology, correlates, natural course, and consequences of unipolar depression in children and adolescents. Using adult depression as a framework, the unique aspects of childhood and adolescence are considered in order to better understand depression within a developmental context. The data suggest that the clinical presentation, correlates, and natural course of depression are remarkably similar across the lifespan. There are, however, important developmental differences. Specifically, the familial and psychological context in which depression develops in youngsters is associated with variability in the frequency and nature of depressive symptoms and comorbid conditions among children and adolescents. Maturational differences have also been identified in the neurobiological correlates of depression. These developmental differences may be associated with the observed variability in clinical response to treatment and longitudinal course. Characterization of the developmental differences will be helpful in developing more specific and effective interventions for youngsters, thereby allowing them to reach their full potential as adults.

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Research works printed but not linked: 24

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Metadata

Authors
Rao, U., & Chen, L.-A.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Rao, Uma
ORCID
Rao, Uma
Venue
Dialogues in Clinical Neuroscience
Publisher
Informa UK Limited
Published
2009-03-31
Volume
11
Issue
1
Pages
45-62
ISSN
  • 1294-8322 (ISSN-L)
  • 1958-5969
DOI
10.31887/dcns.2009.11.1/urao
PMC
PMC2766280
OpenAlex
W1519727848
Cited by
252
References
267
Citations by year
2026: 2 · 2025: 19 · 2024: 32 · 2023: 20 · 2022: 16 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 8 · 2017: 13 · 2016: 13 · 2015: 15 · 2014: 12 · 2013: 20 · 2012: 19
FWCI
16.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute of Mental Health (R01MH062464, R01MH068391, MH62464, MH 68391)
  • National Institute on Drug Abuse (DA14037, DA17805, DA 15131, DA17804, R01DA015131, R01DA017804, R01DA014037, R01DA017805)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
childhood depression, adolescent depression, major depressive disorder, developmental differences, etiology of depression, familial risk, comorbidities, neurobiological correlates, treatment response, phenomenology of depression
MeSH terms
Adolescent, Aging, Brain, Child, Depressive Disorder, Female, Humans, Male, Social Behavior, Stress, Psychological, Comorbidity, Causality, Sex Distribution

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