Depression in adolescents and young adults with cancer
Open accessAbstract
Adolescents and young adults (AYAs) with cancer are at risk for depression due to disruptions in their developmental trajectory, greater physical symptom burden, and increased likelihood of developing aggressive disease. Rates of depression and other psychological disorders are substantially higher in AYAs with cancer when compared with older adults. Psychiatrists caring for these patients must consider the age-appropriate developmental context of these patients along with familial and medical factors that may influence the presentation and treatment of depression. Previous research suggests that psychosocial interventions specifically designed for AYA patients are promising, but studies of psychopharmacology treatments for depression are lacking. There is a pressing need for prospective studies and controlled clinical trials that evaluate the optimal strategies for treating depression in this patient group.
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For many young adult cancer survivors, the impact of treatment is significant and long-lasting, including physical symptoms such as pain and fatigue, psychological distress, and increased risk of long-term health problems such as second cancers and early-onset cardiovascular disease.
“For many YA cancer survivors, the impact of treatment is significant and long-lasting, including difficult physical symptoms (e.g., pain, fatigue) [4–6], psychological distress [6–10], and an increased risk of long-term health problems (e.g., second cancers, early-onset cardiovascular disease) [11–13].”
From Improving symptom management for survivors of young adult cancer: rationale and study protocol for a pilot randomized controlled trial (2024) · cites this paper as [9]
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References 91 · Cited by 108
Research works printed but not linked: 3
- [4]Adolescent and Young Adult Oncology Progress Review Group. Closing the Gap: Research and Care imperatives for Adolescents and Young Adults with Cancer. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, and the LiveStrong Young Adult Alliance. Bethesda, MD: NIH Publication No. 06-6067 2006
- [27]Miller K. Massie MJ. Depressive disorders. In: Holland JC, Breitbart WS, Jacobsen PB, Lederberg MS, Loscalzo MJ, McCorkle R, eds. Psychooncology. New York, NY: Oxford University Press 2010 311 318
- [87]Abraham J. Gulley JL. Allegra CJ. The Bethesda Handbook of Clinical Oncology. Philadelphia, PA: Lippincott Williams & Wilkins 2005
- Authors
- Park, E. M., & Rosenstein, D. L.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Park, Eliza M.
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2015-06-30
- Volume
- 17
- Issue
- 2
- Pages
- 171-180
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- PMC
- PMC4518700
- OpenAlex
- W1902228313
- Cited by
- 108
- References
- 91
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 18 · 2023: 11 · 2022: 22 · 2021: 13 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 1
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- depression, adolescents and young adults, cancer, psychosocial interventions, psychopharmacology, developmental trajectories, physical symptom burden, aggressive disease, family factors, depression treatment
- MeSH terms
- Adolescent, Depression, Female, Humans, Male, Neoplasms, Young Adult
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