The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Genetics of generalized anxiety disorder and related traits
Open accessAbstract
This review serves as a systematic guide to the genetics of generalized anxiety disorder (GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry fear of uncertainty, and neuroticism. We inspect clinical genetic evidence for the familialityl heritability of GAD and cross-disorder phenotypes based on family and twin studies. Recent advances of linkage studies, genome-wide association studies, and candidate gene studies (eg, 5-HTT, 5-HT1A, MAOA, BDNF) are outlined. Functional and structural neuroimaging and neurophysiological readouts relating to peripheral stress markers and psychophysiology are further integrated, building a multilevel disease framework. We explore etiologic factors in gene-environment interaction approaches investigating childhood trauma, environmental adversity, and stressful life events in relation to selected candidate genes (5-HTT, NPSR1, COMT, MAOA, CRHR1, RGS2), Additionally, the pharmacogenetics of selective serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor treatment are summarized (5-HTT, 5-HT2A, COMT, CRHR1). Finally, GAD and trait anxiety research challenges and perspectives in the field of genetics, including epigenetics, are discussed.
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“Monozygotic twins 123-126 and first-degree relatives (depending on the number of probands) 127-130 also have an increased likelihood of developing these disorders.”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [129]
In the citing paper
“clinical genetics have been able to identify various susceptibility genes, including the 5-HT transporter 5-HTT, 5-HT 1A receptor, monoamine oxidase A, catechol-O-methyltransferase, phosphodiesterase 4B and the brain-derived neurotrophic factor (BDNF) gene, involved in specific anxiety-relevant phenotypes and/or in in the aetiology and maintenance of pathological anxiety in a non-specific or disor”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Gottschalk & Domschke, 2017
In the citing paper
“altered DNA methylation patterns in GAD (Gottschalk & Domschke, 2017), PD (Iurato et al., 2017) or adolescents with anxiety disorder (Bortoluzzi et al., 2018) have been found.”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Gottschalk & Domschke, 2017
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Epidemiology of anxiety disorders in the 21st century
Bandelow, B., & Michaelis, S. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/bbandelow · Cited by 2,079
A Review and Meta-Analysis of the Genetic Epidemiology of Anxiety Disorders
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A Population-Based Twin Study of the Relationship Between Neuroticism and Internalizing Disorders
Hettema, J. M., Neale, M. C., Myers, J., Prescott, C. A., & Kendler, K. S. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.857 · Cited by 633
Meta-analysis of genome-wide association studies of anxiety disorders
Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T. B., Aggen, S. H., Adkins, D. E., Wolen, A. R., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.197 · Cited by 558
The Structure of Genetic and Environmental Risk Factors for Anxiety Disorders in Men and Women
Hettema, J. M., Prescott, C. A., Myers, J., Neale, M. C., & Kendler, K. S. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.182 · Cited by 541
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Genetic variation in human NPY expression affects stress response and emotion
Zhou, Z., Zhu, G., Hariri, A. R., Enoch, M.-A., Scott, D., Sinha, R., Virkkunen, M., Mash, D. C., Lipsky, R. H., Hu, X.-Z., et al. (2008) · Nature · doi:10.1038/nature06858 · Cited by 455
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Preventive psychiatry: a blueprint for improving the mental health of young people
Fusar‐Poli, P., Correll, C. U., Arango, C., Berk, M., Patel, V., & Ioannidis, J. P. A. (2021) · World Psychiatry · doi:10.1002/wps.20869 · Cited by 497
Candidate biomarkers in psychiatric disorders: state of the field
Abi‐Dargham, A., Moeller, S. J., Ali, F., DeLorenzo, C., Domschke, K., Horga, G., Jutla, A., Kotov, R., Paulus, M. P., Rubio, J. M., et al. (2023) · World Psychiatry · doi:10.1002/wps.21078 · Cited by 421
Self-citationSartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236
Chen, Y.-H., Bai, J., Wu, D., Yu, S.-F., Qiang, X.-L., Bai, H., Wang, H., & Peng, Z. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.014 · Cited by 231
Manuele, S., Yap, M. B. H., Lin, S. C., Pozzi, E., & Whittle, S. (2023) · Clinical Psychology Review · doi:10.1016/j.cpr.2023.102339 · Cited by 105
Metadata
- Authors
- Gottschalk, M. G., & Domschke, K.
- Affiliations
- Universitätsklinikum Würzburg (DE)
- University of Freiburg (DE)
- Corresponding author
- Domschke, Katharina
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2017-06-30
- Volume
- 19
- Issue
- 2
- Pages
- 159-168
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- PMC
- PMC5573560
- OpenAlex
- W2923926520
- Cited by
- 194
- References
- 67
- Citations by year
- 2026: 8 · 2025: 28 · 2024: 25 · 2023: 38 · 2022: 25 · 2021: 23 · 2020: 23 · 2019: 18 · 2018: 6
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (TRR‐58, SFB TRR 58)
- Bundesministerium für Bildung und Forschung (01EE1402A)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- generalized anxiety disorder, endophenotypes, pathological worry, fear of uncertainty, neuroticism, heritability, familial aggregation, twin studies, family studies, linkage analysis, genome-wide association study, candidate genes, serotonin transporter, monoamine oxidase A, brain-derived neurotrophic factor, stress response, psychophysiology, gene-environment interaction, childhood trauma, life events, pharmacogenetics, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, epigenetics, trait anxiety
- MeSH terms
- Anxiety, Anxiety Disorders, Humans, Norepinephrine, Phenotype, Selective Serotonin Reuptake Inhibitors, Genome-Wide Association Study, Gene-Environment Interaction, Neuroimaging
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