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Using a Mathematical Model to Evaluate the Efficacy of TB Control Measures
Open accessAbstract
We evaluated the efficacy of recommended tuberculosis (TB) infection control measures by using a deterministic mathematical model for airborne contagion. We examined the percentage of purified protein derivative conversions under various exposure conditions, environmental controlstrategies, and respiratory protective devices. We conclude that environmental control cannot eliminate the risk for TB transmission during high-risk procedures; respiratory protective devices, and particularly high-efficiency particulate air masks, may provide nearly complete protection if used with air filtration or ultraviolet irradiation. Nevertheless, the efficiency of these control measures decreases as the infectivity of the source case increases. Therefore, administrative control measures (e.g., indentifying and isolating patients with infectious TB) are the most effective because they substantially reduce the rate of infection.
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Cited by
Miller, S. L., Nazaroff, W. W., Jimenez, J. L., Boerstra, A., Buonanno, G., Dancer, S. J., Kurnitski, J., Marr, L. C., Morawska, L., & Noakes, C. (2021) · Indoor Air · doi:10.1111/ina.12751 · Cited by 734
Particle Sizes of Infectious Aerosols: Implications for Infection Control
Fennelly, K. P. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30323-4 · Cited by 621
Buonanno, G., Morawska, L., & Stabile, L. (2020) · Environment International · doi:10.1016/j.envint.2020.106112 · Cited by 449
“…calculation adopted here is based on the following hypotheses: the infectious virus removal rate is constant, the latent period of the disease is longer than the time scale of the model, and the droplets are instantaneously and evenly distributed in the room (Gammaitoni and Nucci, 1997).”
InfluentialSmith, J. D., MacDougall, C. C., Johnstone, J., Copes, R. A., Schwartz, B., & Garber, G. E. (2016) · Canadian Medical Association Journal · doi:10.1503/cmaj.150835 · Cited by 328
Simulating the Effect of Quarantine on the Spread of the 1918–19 Flu in Central Canada
Sattenspiel, L. (2003) · Bulletin of Mathematical Biology · doi:10.1006/bulm.2002.0317 · Cited by 120
Metadata
- Authors
- Gammaitoni, L., & Nucci, M. C.
- Venue
- Emerging Infectious Diseases
- Published
- 1997-09
- Volume
- 3
- Issue
- 3
- Pages
- 335-342
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- OpenAlex
- W2057599176
- Cited by
- 225
- References
- 0
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
