Vaccine effectiveness estimates, 2004-2005 mumps outbreak, England
Open accessAbstract
The United Kingdom and United States have recently experienced large outbreaks of mumps, which raises concerns about vaccine effectiveness. The effectiveness of the mumps component of the measles, mumps, rubella (MMR) vaccine was estimated using the screening method. In England from January 2004 through March 2005, 312 cases of mumps were reported in children eligible to have received 2 doses of MMR vaccine. Of these children, 52 (16.7%) had received 1 dose of MMR vaccine, and 97 (31.1%) had received 2 doses. Vaccine effectiveness was 88% (95% confidence interval [CI] 83%-91%) for 1 dose and 95% (95% CI 93%-96%) for 2 doses. The effectiveness of 1 dose declined from 96% (95% CI 81%-99%) in 2-year-olds to 66% (95% CI 30%-83%) in 11- to 12-year-olds, and the effectiveness of 2 doses declined from 99% (95% CI 97%-99.5%) in 5- to 6-year-olds to 86% (95% CI 74%-93%) in 11- to 12-year-olds (p<0.001 for 1 or 2 doses). Waning immunity may contribute to mumps outbreaks in older vaccinated populations.
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In several countries, mumps vaccination was not routinely administered.
“in several countries, mumps vaccination was not routinely administered (Cohen 2007; Dayan 2008a).”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Cohen 2007
The Abstract describes routine mumps vaccination in the United Kingdom and refers to countries with high vaccine coverage; it does not say whether several other countries lacked routine vaccination. The Methods likewise concern the UK routine program. Searches for countries without routine mumps immunization found no passage addressing the claim. (LLM, conf=0.73)
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References 33 · Cited by 241
Research works printed but not linked: 4
- [21]COVER/Körner. April to June 1998. Vaccination coverage statistics for children up to five years of age in the United Kingdom. Commun Dis Rep CDR Wkly. 1998; 8: 345– 6.
- [22]Health Protection Agency. COVER programme: July to September 2001. Vaccination coverage statistics for children up to five years of age in the United Kingdom. Commun Dis Rep CDR Wkly. 2002; 12: 7– 10.
- [24]Health Protection Agency. Laboratory confirmed cases of measles, mumps, and rubella, England and Wales: January to March 2003. Commun Dis Rep CDR Wkly. 2003; 13: 11– 4.
- [36]Kassianos GC. Immunization childhood and travel health. 4th ed. Oxford: Blackwell Science Ltd; 2001.
- Authors
- Cohen, C., White, J. M., Savage, E. J., Glynn, J. R., Choi, Y., Andrews, N., Brown, D., & Ramsay, M. E.
- Affiliations
- University of the Witwatersrand (ZA)
- Health Protection Agency (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- Cohen, Cheryl
- ORCID
- Venue
- Emerging infectious diseases
- Published
- 2007-01
- Volume
- 13
- Issue
- 1
- Pages
- 12-7
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC2913658
- OpenAlex
- W2023941564
- Cited by
- 241
- References
- 33
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 9 · 2020: 12 · 2019: 7 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 19 · 2013: 19 · 2012: 12
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- mumps, vaccine effectiveness, MMR vaccine, measles, mumps and rubella, mumps outbreak, waning immunity, two-dose vaccination, children
- MeSH terms
- Child, Child, Preschool, Disease Outbreaks, Drug Administration Schedule, England, Humans, Mumps, Vaccination, Measles-Mumps-Rubella Vaccine
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