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Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseriagonorrhoeae Strain
Open accessAbstract
Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates. Results showed multilocus sequence type 1903; N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) 233; and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. Our results provide further evidence of international transmission of ceftriaxone-resistant N. gonorrhoeae. We recommend increasing awareness of international spread of this drug-resistant strain, strengthening surveillance to include identifying treatment failures and contacts, and strengthening international sharing of data.
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Since 2015, the international spread of ceftriaxone-resistant gonococcal strains has been confirmed.
“Since 2015, the international spread of ceftriaxone-resistant gonococcal strains has been confirmed (10)”
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References 21 · Cited by 239
Research works printed but not linked: 22
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Metadata
- Authors
- Lahra, M. M., Martin, I., Demczuk, W., Jennison, A. V., Lee, K.-I., Nakayama, S.-I., Lefebvre, B., Longtin, J., Ward, A., Mulvey, M. R., Wi, T., Ohnishi, M., & Whiley, D.
- Affiliations
- Royal Adelaide Hospital (AU)
- Corresponding author
- Whiley, David
- ORCID
- Venue
- Emerging Infectious Diseases
- Published
- 2018-04
- Volume
- 24
- Issue
- 4
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC5875269
- OpenAlex
- W2792848668
- Cited by
- 239
- References
- 21
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 22 · 2023: 25 · 2022: 31 · 2021: 30 · 2020: 33 · 2019: 45 · 2018: 13
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- World Health Organization
- Public Health Agency of Canada
- South Eastern Sydney Local Health District
- Australian Government
- NSW Health Pathology
- Public Health Agency
- University of Queensland
- NSW Ministry of Health
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- Neisseria gonorrhoeae, ceftriaxone resistance, international transmission, multilocus sequence typing, antimicrobial resistance surveillance, gonorrhea, travel-associated infection
- MeSH terms
- Ceftriaxone, Gonorrhea, Humans, Microbial Sensitivity Tests, Neisseria gonorrhoeae, Phylogeny, Genome, Bacterial, beta-Lactam Resistance, Polymorphism, Single Nucleotide, Genomics, beta-Lactamase Inhibitors
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