Alzheimer’s Disease and Herbal Combination Therapy: A Comprehensive Review
Open accessAbstract
Alzheimer's disease (AD) was first described in 1907 and got its name after Alois Alzheimer, a German psychiatrist and neuropathologist. This disease starts slow, increasing gradually to worsen in the due course of time. AD is mainly characterized by the associated dementia, which is a decline of cognitive effects such as memory, praxis, and orientation. The dementia is further highlighted by the presence of psychological and behavioral symptoms. Additionally, AD is also associated with the multiple interconnected pathways linked neuropathological changes such as the formation of neurofibrillary tangles and amyloid-β plaques inside the brain. AD therapeutics have been of prime concern over the decades, resulting in the elucidation of promising therapeutic targets. The requirement of AD stage dependent optimized conditions has necessitated a combinatorial approach toward treatment. The priority in AD research has remained to develop disease-modifying and development-reducing drugs for treatment regimens followed during the early and later stages, respectively.
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Herbal medicine for Alzheimer's disease could be multidimensional when the herb being utilized has various effective bioactive compounds.
“As such, herbal medicine for AD could be multidimensional when the herb being utilized has various effective bioactive compounds [42].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [42]
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References 58 · Cited by 30
- Authors
- Pradeep, S., Jain, A. S., Dharmashekara, C., Prasad, S. K., Kollur, S. P., Syed, A., & Shivamallu, C.
- Affiliations
- JSS Academy of Higher Education and Research (IN)
- Amrita Vishwa Vidyapeetham (IN)
- King Saud University (SA)
- Corresponding author
- Kollur, Shiva Prasad
- Shivamallu, Chandan
- ORCID
- Venue
- Journal of Alzheimer s Disease Reports
- Publisher
- SAGE Publications
- Published
- 2020-10-08
- Volume
- 4
- Issue
- 1
- Pages
- 417-429
- ISSN
- 2542-4823 (ISSN-L)
- PMC
- PMC7683102
- OpenAlex
- W3092202660
- Cited by
- 30
- References
- 58
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease Reports (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, herbal combination therapy, dementia, amyloid plaques, neurofibrillary tangles, disease-modifying drugs, symptomatic treatment, cognitive decline
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