Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
Open accessAbstract
BACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro- or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibrational spectral variations of two hydrophilic gels prepared with Poloxamer 407 (PO) or Pluronic F-127 (PL) with the addition of the actives mycosporine-like amino acids and gadusol. METHODS: The structures of these polymers in two different concentrations (20% w/w and 27% w/w) were characterized by rheological studies and Raman spectroscopy. RESULTS: Gels prepared with higher polymer concentration showed larger G' (storage modulus) values. The C-C stretch and the CH2 rocking predominated in the gels containing PL (20% w/w) and this correlated with a less viscous behavior. The mixture of the actives induced higher contributions of Raman peaks related to trans conformation of the C-C bonds located in hydrophilic polymer blocks, whereas the same peaks decreased in the sample containing only gadusol. CONCLUSIONS: Larger tensile strength and elastic component were observed upon increasing polymer concentration, thus evidencing polymer-polymer and/or polymer-polymer-actives interactions. The presence of the actives affected the mechanical properties of the polymer gels. Gadusol particularly seems to alter the conformation of the polymer chains by favoring gauche orientations, in parallel with rising viscoelastic parameters. More stretched arrangements of the polymer are probably induced in the presence of larger concentration of actives, due to specific interactions with their hydrophilic groups.
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These results suggest that MAA may accumulate in the skin, if not through the diet, but further research is needed.
“These results suggest that MAA may accumulate in the skin, if not through the diet but further research is needed [105].”
From Mycosporine-Like Amino Acids for Skin Photoprotection (2019) · cites this paper as [105]
Raman confocal spectroscopy showed that MAA incorporated into polymer gels applied to the skin in vivo penetrate and accumulate at depths of 2 μm in the Stratum corneum at a concentration 103.4% higher than at the surface.
“Raman confocal spectroscopy has shown that MAA incorporated into polymer gels applied to the skin in vivo penetrate and accumulate at depths of 2μm in the Stratum corneum at a concentration 103.4% higher than at the surface.”
From Mycosporine-Like Amino Acids for Skin Photoprotection (2019) · cites this paper as [105]
Uptake of shinorine by human skin cancer A431 cells showed a dose dependent increase from 1 to 1.5 mM after 48 hours, with saturation at concentrations from 1.5 to 2.5 mM.
“A dose dependent increase in shinorine (1-1.5mM) was observed after 48 hours of incubation, but saturation occurred at concentrations from 1.5-2.5mM.”
From Mycosporine-Like Amino Acids for Skin Photoprotection (2019) · cites this paper as [105]
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References 37 · Cited by 3
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- Authors
- Tosato, M. G., Orallo, D. E., Churio, M. S., Martin, A. A., Soto, C. A. T., & Dicelio, L. E.
- Affiliations
- Universidad de Buenos Aires (AR)
- National University of Mar del Plata (AR)
- Laboratório de Espectroscopia Vibracional Biomédica, Universidade do Vale do Paraíba, Sao José dos Campos, Brasil
- Venue
- Biorheology
- Publisher
- SAGE Publications
- Published
- 2014
- Volume
- 51
- Issue
- 4-5
- Pages
- 315-328
- ISSN
- 0006-355X (ISSN-L)
- OpenAlex
- W1779562195
- Cited by
- 3
- References
- 37
- Citations by year
- 2017: 1 · 2015: 2
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biorheology (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas (PIP 112)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Rheology and Fluid Dynamics Studies
- Keywords
- mycosporine-like amino acids, hydrogel rheology, Pluronic F127, polymer-polymer interactions, storage modulus, viscoelasticity, chain conformation, gauche and trans conformations, drug carriers
- MeSH terms
- Amino Acids, Antioxidants, Carbon, Cyclohexanols, Cyclohexanones, Cyclohexylamines, Gels, Glycine, Hydrogen-Ion Concentration, Polymers, Rheology, Spectrum Analysis, Raman, Temperature, Vibration, Viscosity, Poloxamer
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