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Cited by 14Medicinal Plants and Bioactive CompoundsProstate Cancer Treatment and ResearchPI3K/AKT/mTOR signaling in cancer

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Salidroside suppresses proliferation and migration in prostate cancer via the PI3K/AKT pathway

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Liu, Ru-Han, Ma, Teng-Fei, Yang, Qin, Xiao, Wen-Chang, Yin, Lu, Yin, Miao, Zhang, Jin-Song, Wang, Chi-Hua·2023·Cancer Biomarkers
DOI 10.3233/cbm-220454PMC PMC12412865
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Abstract

BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies in men. PCa is difficult to detect in its early stages, and most patients are diagnosed in the middle to late stages. At present, drug therapy for advanced PCa is still insufficient. Some patients develop drug resistance in the later stage of therapy, which leads to tumor recurrence, metastasis and even treatment failure. Therefore, it is crucial to find new and effective drugs to treat prostate cancer. OBJECTIVE: The aim of this study was to investigate the anti-cancer effect of salidroside, an active ingredient in a traditional Chinese herbal medicine, on PCa. METHODS: Two human PCa cell lines, PC3 and DU145, were cultured and treated with salidroside. Cell viability and proliferation ability were analyzed through CCK-8 and colony assays, and cell migration ability was detected by Transwell and Scratch assays. RT-PCR and WB were used to detected the expression levels of moleculars related to cell proliferation, apoptosis, migration, and AKT signaling pathway. Forthmore, we performed rescue experiments with agonist to verify the affected signaling pathway. RESULTS: Salidroside inhibited the proliferation, colony formation, and migration of PCa cells. Meanwhile, apoptosis of PCa cells was enhanced. Moreover, salidroside inhibited PI3K/AKT pathway in PCa cells. The treatment of AKT agonist 740Y-P abrogated the inhibitory effect of salidroside on the PI3K/AKT signaling pathway. CONCLUSIONS: Our study demonstrated that in PCa cells, salidroside inhibites proliferation and migration and promots apoptosis via inhibiting PI3K/AKT pathway.

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Cited by

  • Drug repurposing for cancer therapy

    Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443

    “80 In addition, salidroside was found to impede cancer cell proliferation in HeLa cells and a subcutaneous HeLa-ADR-luc (doxorubicin-resistant derived HeLa-cell lines) cell xenograft mouse model through the activation of apoptosis and inhibition of the PI3K/ Akt/HIF-1 α signaling pathway.”
    Background

Metadata

Authors
Liu, R.-H., Ma, T.-F., Yang, Q., Xiao, W.-C., Yin, L., Yin, M., Zhang, J.-S., & Wang, C.-H.
Affiliations
  • Huanggang Central Hospital (CN)
  • Huanggang Institute of Translational Medicine, Huanggang, Hubei, China
  • Huanggang Disease Control Center, Huanggang, Hubei, China
Corresponding author
  • Zhang, Jin-Song
  • Wang, Chi-Hua
ORCID
Venue
Cancer Biomarkers
Publisher
SAGE Publications
Published
2023-11-20
Volume
38
Issue
3
Pages
321-332
ISSN
  • 1574-0153 (ISSN-L)
  • 1875-8592
DOI
10.3233/cbm-220454
PMC
PMC12412865
OpenAlex
W4385577004
Cited by
14
References
0
Citations by year
2026: 5 · 2025: 4 · 2024: 5
FWCI
1.24
Type
journal article
Language
en
Open access
Locations
  • Cancer Biomarkers (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
salidroside, prostate cancer, PI3K/Akt signaling, cell proliferation, cell migration, apoptosis, Chinese herbal medicine, anticancer activity
MeSH terms
Glucosides, Humans, Male, Neoplasm Recurrence, Local, Phenols, Prostatic Neoplasms, Phosphatidylinositol 3-Kinases, Cell Proliferation, Proto-Oncogene Proteins c-akt

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