Herpes Viruses Increase the Risk of Alzheimer’s Disease: A Meta-Analysis
Abstract
The role of infectious agents in the development of AD has long been debated, in particular, the herpesviridae family. We therefore conducted a meta-analysis to quantitatively assess all published data to establish whether there is an association. We identified studies that looked for the presence of viral DNA in the brain and/or antibody seropositivity in people with AD from four electronic databases. 35 studies met our inclusion criteria (AD cases = 1294; controls = 3059). There was an increased risk for AD when herpesviridae is present in the brain compared to controls [OR 1.38; 95% CI 1.14-1.66]. Sub-analysis showed that APOE ɛ4 and HSV1 together increased the risk of AD development [OR 2.71; 95% CI 1.08-6.80]. HSV1 together with the presence of the APOE ɛ4 allele increases the risk of developing AD.
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AD risk is increased 1.3 times with HSV in the brain, and 2.7 times in concurrent HSV-1/APOE4 carriers compared to controls.
“Meta-analysis from various literature databases indicate that AD risk increased 1.3 times with HSV in the brain, and risk increased 2.7 times in concurrent HSV-1/APOE4 carriers compared to controls [532].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [532]
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References 72 · Cited by 154
- Authors
- Steel, A. J., & Eslick, G. D.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Eslick, Guy D.
- ORCID
- Eslick, Guy D.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2015-07-24
- Volume
- 47
- Issue
- 2
- Pages
- 351-364
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2097556464
- Cited by
- 154
- References
- 72
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 7 · 2023: 49 · 2022: 14 · 2021: 28 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 5 · 2016: 4
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- Alzheimer's disease, herpesvirus
- MeSH terms
- Alzheimer Disease, Antibodies, Viral, Brain, Herpes Simplex, Humans, Risk, Herpesvirus 1, Human, Apolipoprotein E4
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