PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway

Liu, Lu-Shan; Bai, Xue-Qin; Gao, Ya; Wu, Qi; Ren, Zhong; Li, Qing; Pan, Li-Hong; He, Ni-Ya; Peng, Juan; Tang, Zhi-Han

doi:10.3233/jad-161136

PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway

Background Hyperlipidemia is a risk factor for neurodegenerative diseases. Proprotein convertase subtilisin / Kexin type 9 (PCSK9) degrades hepatic low-density lipoprotein receptor (LDLR) to regulate lipid metabolism. It is unclear if PCSK9 plays a role in neurodegenerative diseases. Objective Th…