Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer’s Disease and Correlates with Cognitive Impairment

Oeckl, Patrick; Halbgebauer, Steffen; Anderl-Straub, Sarah; Steinacker, Petra; Huss, André M.; Neugebauer, Hermann; von Arnim, Christine A.F.; Diehl-Schmid, Janine; Grimmer, Timo; Kornhuber, Johannes; Lewczuk, Piotr; Danek, Adrian; Consortium for Frontotemporal Lobar Degeneration German; Ludolph, Albert C.; Otto, Markus

doi:10.3233/jad-180325

Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer’s Disease and Correlates with Cognitive Impairment

Reliable blood biomarkers for Alzheimer’s disease (AD) are missing. We measured astroglial GFAP in patients with AD ( n = 28), frontotemporal dementia (bvFTD, n = 35), Parkinson’s disease ( n = 11), Lewy body dementias ( n = 19), and controls ( n = 34). Serum GFAP was increased in AD ( p