Synaptic remodeling during aging and in Alzheimer's disease
Abstract
Cognitive functioning is dependent on synapse density in the brain. Factors modulating synapse density might include the balance between synaptic pruning and sprouting. Loss of synapses during aging might explain cognitive decline and while previous reports have suggested a 10-15% synapse loss occurs during the normal aging process, more recent studies have found that decline in synaptic density only occurs after 65 years of age. In this context, the main objective of this manuscript is to discuss the findings of our 1993 study in light of more recent studies in aging, synapses and Alzheimer's disease.
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Synapses are major sites of Aβ pathology and generation.
“Synapses have long been viewed as critical sites of AD pathology [6, 28, 112, 119, 168] and diverse evidence had supported that synapses are major sites of Aβ pathology and also generation.”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [112]
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References 106 · Cited by 132
- Authors
- Masliah, E., Crews, L., & Hansen, L.
- Affiliations
- University of California San Diego (US)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2006-07-27
- Volume
- 9
- Issue
- s3
- Pages
- 91-99
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W127741752
- Cited by
- 132
- References
- 106
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P50AG005131, AG-5131, AG022074, AG 18440, P01AG022074)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- synaptic remodeling, synaptic density
- MeSH terms
- Aged, Aging, Alzheimer Disease, Brain, Humans, Neuronal Plasticity, Neurons, Synapses, Amyloid beta-Protein Precursor, Cell Death
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