MiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study
Open accessAbstract
MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N=19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P< 0.05) and neurofibrillary tangle counts (P< 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses.
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Several miRNAs regulating BACE1 expression are down-regulated in the affected regions of AD brains.
“Among those, several miRNAs regulating BACE1 expression are known to be down-regulated in the affected regions of AD brains (Hebert et al. 2008, Nelson & Wang 2010, Long et al. 2014, Lau et al. 2013).”
From miR‐186 is decreased in aged brain and suppresses <scp>BACE</scp>1 expression (2016) · cites this paper as Nelson & Wang 2010
The Introduction identifies miR-107 as a BACE1-targeting miRNA down-regulated in AD cerebral cortical gray matter, and the Discussion reports that this validation study supports its decrease as AD progresses. But the Methods state that no other miRNA levels were evaluated, so this source supports one example rather than the claim that several such miRNAs are down-regulated. (LLM, conf=0.86)
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References 25 · Cited by 222
Research works printed but not linked: 20
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- Authors
- Nelson, P. T., & Wang, W.-X.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Nelson, Peter T.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-07-08
- Volume
- 21
- Issue
- 1
- Pages
- 75-79
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC2910235
- OpenAlex
- W1571425219
- Cited by
- 222
- References
- 25
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 11 · 2023: 15 · 2022: 7 · 2021: 16 · 2020: 19 · 2019: 19 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 18 · 2014: 16 · 2013: 16 · 2012: 9
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- Funders
- University of Kentucky
- National Institutes of Health
- National Institute on Aging (P30AG028383)
- National Institute of Neurological Disorders and Stroke (R01NS061933, K08NS050110)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- miR-107, microRNA expression
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Male, Down-Regulation, Disease Progression, Neocortex, MicroRNAs, Validation Studies as Topic
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