The DOI matches its Crossref record.
Genetic Deficiency of Plasma Lipoprotein-Associated Phospholipase A2 (PLA2G7 V297F Null Mutation) and Risk of Alzheimer's Disease in Japan
Abstract
High plasma lipoprotein phospholipase A2 activity (Lp-PLA2) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA2 gene - PLA2G7 V279F - is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or age at onset of AD: logistic regression OR 0.98 (95% CI 0.86-1.12, p=0.81) per additional null allele, adjusted for age/age at onset, gender, and APOE ε4. Genetic deficiency of Lp-PLA2 activity is not associated with a reduced risk of AD in the Japanese population.
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Pla2g7 is associated with AD.
“Pla2g7 was increased in astrocyte ApoE lipoproteins (Fig. 5B, Supplemental Table S8) and is associated with AD (62).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [62]
Mutations in Lp-PLA2 are associated with increased risk for AD.
“Mutations in Lp-PLA2 have been associated with increased risk for AD (62)”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [62]
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Mendelian randomization studies: a review of the approaches used and the quality of reporting
Boef, A. G. C., Dekkers, O. M., & le Cessie, S. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv071 · Cited by 610
Lipoprotein‐associated phospholipase A2: The story continues
Huang, F., Wang, K., & Shen, J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21597 · Cited by 212
Strickland, M. R., Wang, Z., Golden, L. R., Wang, H., Lu, P., Ren, Y., Tabor, G. T., Zhao, N., Ulrich, J. D., Han, X., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101000 · Cited by 8
Metadata
- Authors
- Koshy, B., Miyashita, A., St. Jean, P., Stirnadel, H., Kaise, T., Rubio, J. P., Mooser, V., Kuwano, R., & Irizarry, M. C.
- Affiliations
- Genetics, GlaxoSmithKline, Research Triangle Park, NC, USA
- Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan
- WW Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA
- Epidemiology, GlaxoSmithKline, Tokyo, Japan
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-09-02
- Volume
- 21
- Issue
- 3
- Pages
- 775-780
- ISSN
- 1875-8908
- 1387-2877
- Cited by
- 17
- References
- 0
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