Association between Bone Mineral Density and the Risk of Alzheimer's Disease
Abstract
Alzheimer's disease (AD) and osteoporosis are common chronic degenerative disorders which are strongly associated with advanced age. Some studies suggest that low bone mineral density (BMD) is related to the increased risk of AD. We conducted a 5-year prospective study to exam the association between BMD and the risk of AD in a cohort of Chinese elderly people. Of 3263 community residents aged 65 years and over, 2019 were enrolled into the study and followed up annually for 5 years. At baseline demographic data, smoking and drinking status, medical history, cognitive status, and blood samples were collected. BMD was measured by dual energy X-ray absorptiometry (DEXA) scanning at baseline and during follow-up. Cox proportional hazards analysis was used to evaluate the association with BMD and incidence of AD. Over the follow-up of 5 years, AD developed in 132 subjects. Baseline BMD, bone loss rate, current smoking, and daily drinking were associated with increased risk of AD, while higher baseline plasma leptin level was associated with decreased risk of AD, in both women and men. Low BMD and increased loss rate of BMD were associated with higher risk of AD. Cigarette smoking, alcohol drinking, and lower leptin level are risk factors for AD. Uncovering the relation linking osteoporosis and AD is important for understanding the pathogenesis and developing therapeutic strategies for these two common disorders afflicting elderly people.
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Low bone mineral density can predict risk of AD years before dementia diagnosis.
“Notably, low bone mineral density can predict risk of AD years before dementia diagnosis26,28,29.”
From Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis (2025) · cites this paper as [29]
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“Increasing evidence has indicated that the decrease in BMD is associated with the development of AD (2)and that OP and hip fractures are common complications observed in patients with AD, but whether these phenomena are part of a pathological process during the development of AD or are a ‘by-product’ of disuse OP caus…”
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“48 times more likely to develop AD than group with the highest BMD (Zhou et al., 2011).”
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Administration of DNA Plasmid Coding Protein Aggregating Domain Induces Inflammatory Bone Loss
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“Moreover, a low BMD has been associated with an increased risk of Alzheimer’s Disease (Kostev et al. 2018; Lui et al. 2003; Tan et al. 2005; Zhang et al. 2022; Zhou et al. 2011; Xiao et al. 2023).”
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7. Novel and current approaches to dietary and non-dietary bone metabolism regulation
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- Authors
- Zhou, R., Deng, J., Zhang, M., Zhou, H.-D., & Wang, Y.-J.
- Affiliations
- Army Medical University (CN)
- Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China
- Corresponding author
- Deng, Juan
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2011-03-29
- Volume
- 24
- Issue
- 1
- Pages
- 101-108
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1498555451
- Cited by
- 123
- References
- 0
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, bone mineral density
- MeSH terms
- Aged, Alzheimer Disease, Female, Follow-Up Studies, Humans, Male, Osteoporosis, Prospective Studies, Risk Factors, Cohort Studies, Bone Density, Leptin, Asian People
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