Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
Open accessAbstract
Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with Alzheimer's disease (AD), including stress stimuli such as oxidative stress and inflammation. In both diseases, the detrimental intra- and extracellular deposits have many similarities. Aging, hypercholesterolaemia, hypertension, obesity, arteriosclerosis, and smoking are risk factors to develop AMD and AD. Cellular aging processes have similar organelle and signaling association in the retina and brain tissues. However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed.
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AD, PD, and glaucoma have similar mechanisms of cell injury and deposition of protein aggregates in specific anatomical areas.
“they have similar mechanisms of cell injury and deposition of protein aggregates in specific anatomical areas (Wostyn et al., 2010; Kaarniranta et al., 2011; Ghiso et al., 2013)”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Kaarniranta et al., 2011
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References 208 · Cited by 248
Research works printed but not linked: 1
- Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G (2007) Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol 66, 525-532. Erratum in: J Neuropathol Exp Neurol 2007; 66, 674.
- Authors
- Kaarniranta, K., Salminen, A., Haapasalo, A., Soininen, H., & Hiltunen, M.
- Affiliations
- University of Eastern Finland (FI)
- Corresponding author
- Kaarniranta, Kai
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2011-05-30
- Volume
- 24
- Issue
- 4
- Pages
- 615-631
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1553154837
- Cited by
- 248
- References
- 208
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 20 · 2023: 6 · 2022: 16 · 2021: 19 · 2020: 27 · 2019: 20 · 2018: 18 · 2017: 9 · 2016: 14 · 2015: 20 · 2014: 19 · 2013: 20 · 2012: 14
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Ögonfonden
- Academy of Finland (5772708, 5503726)
- Suomen Kulttuurirahasto
- Tekes
- Kuopion Yliopistollinen Sairaala (5772708)
- Päivikki ja Sakari Sohlbergin Säätiö
- Silmäsäätiö
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related macular degeneration, Alzheimer's disease
- MeSH terms
- Aging, Alzheimer Disease, Animals, Eye Diseases, Humans, Macular Degeneration
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